MAPRE2 and CLASP2

Number of citations of the paper that reports this interaction (PubMedID 15631994)
34

Data Source:
HPRD (in vitro, in vivo)

		MAPRE2	CLASP2
Description		microtubule associated protein RP/EB family member 2	cytoplasmic linker associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Microtubule Plus-end Spindle Midzone	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Cell Leading Edge Ruffle Membrane Cell Projection Axonal Growth Cone Basal Cortex Mitotic Spindle Glutamatergic Synapse Cortical Microtubule Plus-end
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding Actin Filament Binding Protein Tyrosine Kinase Binding
	Biological Process	Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of ARF Protein Signal Transduction Protein Localization To Microtubule Spindle Assembly Cell Division Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Disassembly	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Regulation Of Axon Extension Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Regulation Of Microtubule-based Process Regulation Of Actin Cytoskeleton Organization Microtubule Anchoring Platelet-derived Growth Factor Receptor-beta Signaling Pathway Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Presynaptic Cytoskeleton Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brugada syndrome ( 35210625) Cerebrospinal fluid AB1-42 levels ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Metabolite levels ( 23823483)	Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)
Interacting Genes		25 interacting genes: APC APP AURKA AURKB CASK CDK2 CDK4 CLASP2 CLIP1 DDIT4L FBXO7 GTSE1 LMNA LMO2 LNX1 MAPRE3 NIF3L1 PAXIP1 RBM10 RBM6 SLAIN2 TRAF1 TRAIP TXN2 UBC	15 interacting genes: ADRB2 AKT1 CCR4 CLIP1 CLIP2 CREBBP CSNK2A1 ERBB2 FEZ1 FEZ2 MAPRE1 MAPRE2 PYGM RBFOX2 SRPK2
Entrez ID		10982	23122
HPRD ID		16157	12054
Ensembl ID		ENSG00000166974	ENSG00000163539
Uniprot IDs		Q15555	A0A0U1RQI6 A0A804HJG7 E7ERI8 E7EW49 J3KR49 O75122
PDB IDs			3WOY 5NR4 8WHH 8WHI 8WHJ 8WHK 8WHL
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Plus-end Binding Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Microtubule-based Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Supramolecular Fiber Organization Cytoplasmic Microtubule Regulation Of Microtubule Polymerization Centrosome Microtubule Cytoskeleton Organization Kinetochore Cell Cycle Phase Transition Microtubule Plus-end Spindle Midzone Regulation Of Cell Cycle Process Microtubule Spindle Assembly Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Depolymerization Positive Regulation Of Cellular Component Organization Cytoskeleton Chromosome Passenger Complex Spindle Microtubule Microtubule Binding Regulation Of Organelle Organization Positive Regulation Of Mitotic Cell Cycle Cell Division Membraneless Organelle Assembly Mitotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Binding Cell Cycle G2/M Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Identical Protein Binding Regulation Of Cell Cycle G1/S Phase Transition Protein Serine Kinase Activity Nuclear Lamina	Microtubule Plus-end Binding Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Macroautophagy Regulation Of Microtubule-based Process Negative Regulation Of Macroautophagy Microtubule Regulation Of Autophagy Regulation Of Organelle Organization Negative Regulation Of Autophagosome Assembly Regulation Of Cellular Component Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microtubule Binding Protein Localization To Microtubule Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Autophagy Protein Localization To Organelle Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Organization Spindle Midzone Negative Regulation Of Catabolic Process Identical Protein Binding Positive Regulation Of Cell Growth 14-3-3 Protein Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization Intracellular Signal Transduction Cell Cortex Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Organelle Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Organelle Organization Peptidyl-serine Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Intracellular Signaling Cassette Negative Regulation Of Translational Initiation Protein Kinase Activity Regulation Of TRNA Methylation Regulation Of Transcription By RNA Polymerase I Neuron Projection Guidance Axon Guidance Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Protein Localization To Cytoskeleton Protein Localization To Astral Microtubule Response To Epidermal Growth Factor Cytoplasmic Microtubule Positive Regulation Of Growth
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