MAPRE2 and TXN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAPRE2	TXN2
Description		microtubule associated protein RP/EB family member 2	thioredoxin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Microtubule Plus-end Spindle Midzone	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding	Protein Binding Protein-disulfide Reductase Activity
	Biological Process	Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of ARF Protein Signal Transduction Protein Localization To Microtubule Spindle Assembly Cell Division Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Disassembly	Cell Redox Homeostasis
Pathways			Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Brugada syndrome ( 35210625) Cerebrospinal fluid AB1-42 levels ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Metabolite levels ( 23823483)
Interacting Genes		25 interacting genes: APC APP AURKA AURKB CASK CDK2 CDK4 CLASP2 CLIP1 DDIT4L FBXO7 GTSE1 LMNA LMO2 LNX1 MAPRE3 NIF3L1 PAXIP1 RBM10 RBM6 SLAIN2 TRAF1 TRAIP TXN2 UBC	78 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B CSTPP1 DCTD DDIT3 ETHE1 FAM9B FHL5 GOLGA6L9 GPRASP2 GPRASP3 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32
Entrez ID		10982	25828
HPRD ID		16157	07161
Ensembl ID		ENSG00000166974	ENSG00000100348
Uniprot IDs		Q15555	Q99757
PDB IDs			1UVZ 1W4V 1W89
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Plus-end Binding Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Microtubule-based Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Supramolecular Fiber Organization Cytoplasmic Microtubule Regulation Of Microtubule Polymerization Centrosome Microtubule Cytoskeleton Organization Kinetochore Cell Cycle Phase Transition Microtubule Plus-end Spindle Midzone Regulation Of Cell Cycle Process Microtubule Spindle Assembly Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Depolymerization Positive Regulation Of Cellular Component Organization Cytoskeleton Chromosome Passenger Complex Spindle Microtubule Microtubule Binding Regulation Of Organelle Organization Positive Regulation Of Mitotic Cell Cycle Cell Division Membraneless Organelle Assembly Mitotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Binding Cell Cycle G2/M Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Identical Protein Binding Regulation Of Cell Cycle G1/S Phase Transition Protein Serine Kinase Activity Nuclear Lamina	Identical Protein Binding Protein Binding Microtubule Organizing Center Organelle Organization Cytoskeleton Organization Cytoskeleton Membraneless Organelle Assembly Spindle Assembly Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Synaptonemal Complex Microtubule Cytoskeleton Organization Cytoplasm Microtubule-based Process
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