MON1B and VPS11

Number of citations of the paper that reports this interaction (PubMedID 20434987)
0

Data Source:
BioGRID (two hybrid)

		MON1B	VPS11
Description		MON1 vesicular trafficking associated B	VPS11 core subunit of CORVET and HOPS complexes
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mon1-Ccz1 Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Vesicle Tethering Complex
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Vacuole Vesicle-mediated Transport Early Viral Transcription Late Viral Transcription	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs	SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Immune response to measles-mumps-rubella vaccine ( 24811271) Metabolite levels ( 23823483) Multisite chronic pain ( 31194737 33830993) Number of sexual partners ( 30643258)	Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: RABGEF1 VPS11 VPS16 VPS18 VPS33A VPS41	33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 GRSF1 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45
Entrez ID		22879	55823
HPRD ID		12342	12258
Ensembl ID		ENSG00000103111	ENSG00000160695
Uniprot IDs		B4DKA0 E7EW32 Q6ZR87 Q7L1V2	A0A087WXL6 B7Z879 Q9H270
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex CORVET Complex Endosome To Lysosome Transport Clathrin-coated Vesicle Vesicle Fusion Organelle Membrane Fusion Early Endosome Lysosomal Transport Organelle Fusion Late Endosome Membrane Late Endosome Membrane Fusion Vacuolar Transport AP-3 Adaptor Complex Endosome Endosome Membrane Autophagosome Autophagy Vesicle Organization Lysosomal Membrane Regulation Of Protein-containing Complex Assembly Protein Transport Vesicle-mediated Transport Lysosome Intracellular Transport Establishment Of Protein Localization Intracellular Protein Transport Membrane Organization Cellular Localization Establishment Of Localization In Cell Vesicle Tethering Complex Intracellular Protein Localization Cytoplasmic Vesicle Clathrin Complex Organelle Localization Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Vacuole Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Catabolic Process Syntaxin Binding Autophagosome Maturation Lysosome Localization Ubiquitin Protein Ligase Activity Vesicle Docking Endocytic Vesicle	Late Endosome Membrane Docking Vesicle Organization Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Endosome Vesicle-mediated Transport Intracellular Protein Transport Membrane Fusion Early Endosome Vacuolar Transport Endosome To Lysosome Transport Intracellular Protein Localization Lysosomal Transport Positive Regulation Of Catabolic Process Establishment Of Protein Localization Protein Transport Organelle Localization Macromolecule Catabolic Process Catabolic Process Vesicle Docking SNARE Binding Regulation Of Protein Localization Positive Regulation Of Protein Catabolic Process Cellular Localization Chloride Channel Inhibitor Activity CORVET Complex Clathrin-coated Vesicle Intracellular Transport Organelle Localization By Membrane Tethering Positive Regulation Of Early Endosome To Late Endosome Transport Autophagosome Membrane Organization Endosome Organization Late Endosome Membrane Positive Regulation Of Protein Localization To Early Endosome SNAP Receptor Activity Endosomal Transport Positive Regulation Of Protein Localization To Endosome Establishment Of Localization In Cell Endosome Membrane SNARE Complex HOPS Complex Autophagy Autophagosome Maturation Syntaxin Binding Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Metabolic Process
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