MON1B and RABGEF1

Number of citations of the paper that reports this interaction (PMID 20434987)
96

Data Source:
BioGRID (pull down)

		MON1B	RABGEF1
Gene Name		MON1 secretory trafficking family member B	RAB guanine nucleotide exchange factor (GEF) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endomembrane System	Early Endosome Vesicle Recycling Endosome
	Molecular Function	Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Vesicle-mediated Transport	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Protein Ubiquitination Positive Regulation Of Rab GTPase Activity Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Kit Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Aortic root size ( 21223598)
Protein-Protein Interactions		6 interactors: RABGEF1 VPS11 VPS16 VPS18 VPS33A VPS41	30 interactors: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 GGA1 GGA2 HRAS KXD1 L1CAM MON1A MON1B RAB21 RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		22879	27342
HPRD ID		12342	11477
Ensembl ID			ENSG00000243335
Uniprot IDs		B4DDZ0 E7EW32 Q6ZR87 Q7L1V2	B4DZM7 Q9UJ41
PDB IDs			1TXU 2C7M 2C7N 2OT3
Enriched GO Terms of Interacting Partners?		Regulation Of SNARE Complex Assembly Protein Transport Establishment Of Protein Localization Regulation Of Vesicle Fusion Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Cellular Localization Cellular Protein Localization Vesicle-mediated Transport Intracellular Transport Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Complex Assembly Transport Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Negative Regulation Of Kit Signaling Pathway Regulation Of Vacuole Fusion, Non-autophagic Vacuole Fusion, Non-autophagic Interaction With Host Vacuole Organization Regulation Of Cellular Component Organization Viral Life Cycle Regulation Of Organelle Organization Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Mast Cell Activation Exocytosis Protein Targeting Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Vacuole Organization Negative Regulation Of Leukocyte Migration Platelet Formation Platelet Morphogenesis Protein Targeting To Vacuole Regulation Of Developmental Pigmentation Regulation Of Mast Cell Degranulation Secretion By Cell Establishment Of Protein Localization To Vacuole Viral Process Endosome Organization Lysosome Localization Regulation Of Mast Cell Activation Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-6 Production	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Intracellular Transport Of Virus Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Intracellular Transport Positive Regulation Of Innate Immune Response Establishment Of Localization In Cell Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Transport Innate Immune Response DNA-templated Transcription, Initiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Type I Interferon Production Viral Protein Processing Response To Growth Factor Establishment Of Protein Localization Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Immune Response-regulating Signaling Pathway Cellular Localization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immune Response Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?