MON1B and VPS33A

Number of citations of the paper that reports this interaction (PubMedID 20434987)
0

Data Source:
BioGRID (pull down)

		MON1B	VPS33A
Description		MON1 vesicular trafficking associated B	VPS33A core subunit of CORVET and HOPS complexes
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mon1-Ccz1 Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Clathrin Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Targeting To Vacuole Vesicle-mediated Transport Early Viral Transcription Late Viral Transcription	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Lysosomal Lumen PH Pigmentation Regulation Of Developmental Pigmentation Autophagosome Maturation
Pathways		RAB GEFs exchange GTP for GDP on RABs	SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Immune response to measles-mumps-rubella vaccine ( 24811271) Metabolite levels ( 23823483) Multisite chronic pain ( 31194737 33830993) Number of sexual partners ( 30643258)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: RABGEF1 VPS11 VPS16 VPS18 VPS33A VPS41	7 interacting genes: MON1A MON1B ROPN1 TNKS VPS11 VPS16 VPS18
Entrez ID		22879	65082
HPRD ID		12342	15651
Ensembl ID		ENSG00000103111	ENSG00000139719
Uniprot IDs		B4DKA0 E7EW32 Q6ZR87 Q7L1V2	F5H6Y0 Q96AX1
PDB IDs			4BX8 4BX9
Enriched GO Terms of Interacting Partners?		Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex CORVET Complex Endosome To Lysosome Transport Clathrin-coated Vesicle Vesicle Fusion Organelle Membrane Fusion Early Endosome Lysosomal Transport Organelle Fusion Late Endosome Membrane Late Endosome Membrane Fusion Vacuolar Transport AP-3 Adaptor Complex Endosome Endosome Membrane Autophagosome Autophagy Vesicle Organization Lysosomal Membrane Regulation Of Protein-containing Complex Assembly Protein Transport Vesicle-mediated Transport Lysosome Intracellular Transport Establishment Of Protein Localization Intracellular Protein Transport Membrane Organization Cellular Localization Establishment Of Localization In Cell Vesicle Tethering Complex Intracellular Protein Localization Cytoplasmic Vesicle Clathrin Complex Organelle Localization Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Vacuole Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Catabolic Process Syntaxin Binding Autophagosome Maturation Lysosome Localization Ubiquitin Protein Ligase Activity Vesicle Docking Endocytic Vesicle	Vacuolar Transport CORVET Complex Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Intracellular Protein Localization Protein Transport Intracellular Protein Transport Vesicle Tethering Complex Establishment Of Protein Localization Endosome To Lysosome Transport Mon1-Ccz1 Complex Clathrin-coated Vesicle Autophagosome Vesicle Fusion Organelle Membrane Fusion Lysosomal Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Organelle Fusion Vesicle-mediated Transport Late Endosome Membrane Late Endosome Membrane Fusion Intracellular Transport Vacuole Organization Protein Localization To Organelle Cellular Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Membrane Syntaxin Binding Autophagy Protein Targeting To Vacuole Vesicle Organization Early Endosome Vesicle Docking Establishment Of Protein Localization To Vacuole Lysosomal Membrane Organelle Localization By Membrane Tethering Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Endosome Organization Regulation Of Protein-containing Complex Assembly Membrane Docking Protein Localization To Vacuole Lysosome Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Early Viral Transcription Vacuole Fusion, Non-autophagic
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