ZNF510 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		ZNF510	MLH3
Description		zinc finger protein 510	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways		Generic Transcription Pathway	Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS			Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: APC AURKA BRAF BUB1 CCND1 CDH1 CTNNA1 DLC1 EGFR FBXW7 MLH3 MSH2 ODC1 PDGFRL PTPN12 PTPRJ SMAD1 SMAD2 SMAD4 STK11 TGFBR2	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		22869	27030
HPRD ID		18348	05094
Ensembl ID		ENSG00000081386	ENSG00000119684
Uniprot IDs		Q6NUI8 Q9Y2H8	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Gamma-catenin Binding Animal Organ Development Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Differentiation SMAD Protein Complex Response To Growth Factor Cell Population Proliferation Heteromeric SMAD Protein Complex Developmental Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Secondary Palate Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle Phase Transition Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Negative Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus I-SMAD Binding Response To UV Negative Regulation Of Cell Population Proliferation Ubiquitin Protein Ligase Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Homomeric SMAD Protein Complex Protein Kinase Activity Regulation Of Mitotic Cell Cycle Endocardial Cushion Morphogenesis Response To Light Stimulus Regulation Of ERBB Signaling Pathway Animal Organ Morphogenesis Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Cell Development Cell Junction Regulation Of Protein Metabolic Process Activin Responsive Factor Complex Developmental Growth Regulation Of Cell Communication Regulation Of Signaling Catenin Complex Kinase Activity Ruffle Membrane Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Anchoring Junction Beta-catenin Binding	Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration
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