NHERF2 and SLC22A9

Number of citations of the paper that reports this interaction (PubMedID 15553237)
0

Data Source:
HPRD (two hybrid)

		NHERF2	SLC22A9
Description		NHERF family PDZ scaffold protein 2	solute carrier family 22 member 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Organic Anion Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Short-chain Fatty Acid Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Lipid Transport Hormone Transport Organic Anion Transport Short-chain Fatty Acid Transmembrane Transport Sodium-independent Organic Anion Transport Transmembrane Transport
Pathways
Drugs
Diseases
GWAS			Economic and political preferences ( 22566634) Sex hormone levels ( 26014426) Thyroxine levels ( 30824882)
Interacting Genes		46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1	3 interacting genes: NHERF1 NHERF2 NHERF4
Entrez ID		9351	114571
HPRD ID		05946	06982
Ensembl ID		ENSG00000065054	ENSG00000149742
Uniprot IDs		H3BQS0 Q15599	Q8IVM8
PDB IDs		2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis	Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Phosphatase Binding Localization Within Membrane Apical Part Of Cell Beta-catenin Binding Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Molecular Adaptor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Endomembrane System Cellular Localization Intracellular Protein Localization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Glutathione Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Cerebrospinal Fluid Circulation Regulation Of CGMP-mediated Signaling Ion Channel Inhibitor Activity Plasma Membrane Protein Complex Stereocilium Tip Oligopeptide Transport Establishment Of Epithelial Cell Apical/basal Polarity
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