SLC9A3R2 and P2RY1

Number of citations of the paper that reports this interaction (PMID 9671706)
87

Data Source:
HPRD (in vitro)

		SLC9A3R2	P2RY1
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	purinergic receptor P2Y, G-protein coupled, 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Vesicular Exosome	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding	Receptor Activity Protein Binding ATP Binding A1 Adenosine Receptor Binding ADP Binding G-protein Coupled Purinergic Nucleotide Receptor Activity ATP-activated Nucleotide Receptor Activity ADP-activated Nucleotide Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Protein Complex Assembly Negative Regulation Of Phosphatidylinositol 3-kinase Signaling	Positive Regulation Of Protein Phosphorylation Adenosine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Blood Coagulation Response To Mechanical Stimulus Regulation Of Receptor Activity Negative Regulation Of Norepinephrine Secretion Sensory Perception Of Pain Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Vasodilation Eating Behavior Positive Regulation Of Ion Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Negative Regulation Of Binding Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Relaxation Of Muscle
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Signal amplification Metabolic disorders of biological oxidation enzymes GPCR ligand binding P2Y receptors G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-2) ( 22610502)
Protein-Protein Interactions		35 interactors: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDPK1 PDZK1 PIK3CA PLCB3 PODXL PRKACA PTEN PTH1R RDX SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1	3 interactors: ADORA1 SLC9A3R1 SLC9A3R2
Entrez ID		9351	5028
HPRD ID		05946	03103
Ensembl ID		ENSG00000065054	ENSG00000169860
Uniprot IDs		Q15599	P47900
PDB IDs		2D11 2HE4 2OCS	1Y36
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Ion Homeostasis Transmembrane Transport Regulation Of Kinase Activity Regulation Of Ion Transport Positive Regulation Of Ion Transport Regulation Of Protein Phosphorylation Homeostatic Process Positive Regulation Of Transport Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Ion Transmembrane Transport Cellular Cation Homeostasis Organic Anion Transport Cellular Ion Homeostasis Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Positive Regulation Of Protein Kinase Activity Blood Circulation Positive Regulation Of Cellular Protein Metabolic Process Anion Transport Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Transport Positive Regulation Of Protein Phosphorylation Sodium-independent Organic Anion Transport Carnitine Transport Cellular Chemical Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Monocarboxylic Acid Transport Sperm Capacitation Anion Transmembrane Transport Regulation Of Cellular Component Organization Sodium Ion Transport Inorganic Anion Transport Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Quaternary Ammonium Group Transport Positive Regulation Of Cytosolic Calcium Ion Concentration	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Excretion Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Ion Transport Renal System Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Long Term Synaptic Depression Renal Phosphate Ion Absorption Negative Regulation Of Neurotrophin Production Positive Regulation Of Nucleoside Transport Negative Regulation Of Signaling Negative Regulation Of Cell Migration Negative Regulation Of Mucus Secretion Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Locomotion Regulation Of Long Term Synaptic Depression Regulation Of Intracellular Signal Transduction Renal Sodium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Glutamate Secretion Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Transport Negative Regulation Of Vasodilation Negative Regulation Of Striated Muscle Contraction Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Intracellular Signal Transduction Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Relaxation Of Vascular Smooth Muscle Bile Acid Secretion Relaxation Of Smooth Muscle Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Regulation Of Glutamate Secretion Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Adenosine Receptor Signaling Pathway Regulation Of Glomerular Filtration
Tagcloud ?			bipolar bpd creb1 dd depressed depression depressive dysregulation examining females financial hpa lesser leukocytes mdd medication nfkb1 nr3c1 oxtr p2rx1 p2rx7 purinergic qpcr refractory replicated served sparc trpv1 trpv4
Tagcloud (Difference) ?			bipolar bpd creb1 dd depressed depression depressive dysregulation examining females financial hpa lesser leukocytes mdd medication nfkb1 nr3c1 oxtr p2rx1 p2rx7 purinergic qpcr refractory replicated served sparc trpv1 trpv4
Tagcloud (Intersection) ?