NHERF2 and KCNJ1

Number of citations of the paper that reports this interaction (PubMedID 14604981)
0

Data Source:
BioGRID (pull down, two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		NHERF2	KCNJ1
Description		NHERF family PDZ scaffold protein 2	potassium inwardly rectifying channel subfamily J member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Nucleotide Binding Inward Rectifier Potassium Channel Activity Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Kidney Development Tissue Homeostasis Monoatomic Ion Transport Potassium Ion Transport Post-embryonic Development Gene Expression Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Renal Sodium Ion Absorption Circulatory System Development Potassium Ion Import Across Plasma Membrane
Pathways			Potassium transport channels
Drugs			Bethanidine Glimepiride Minoxidil Acetohexamide Ritodrine Tolbutamide Glymidine Yohimbine Agmatine Butamben
Diseases			Bartter syndrome
GWAS
Interacting Genes		46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1	6 interacting genes: GOLGA3 NHERF1 NHERF2 PRKCD SGK1 SH3RF1
Entrez ID		9351	3758
HPRD ID		05946	08981
Ensembl ID		ENSG00000065054	ENSG00000151704
Uniprot IDs		H3BQS0 Q15599	A8K432 P48048
PDB IDs		2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Chloride Channel Regulator Activity Regulation Of Apoptotic Signaling Pathway Response To Aldosterone Positive Regulation Of Apoptotic Signaling Pathway Renal Sodium Ion Transport Protein-membrane Adaptor Activity Response To Mineralocorticoid Positive Regulation Of Transporter Activity Renal Absorption Endomembrane System Phosphatase Binding Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To UV Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Cellular Response To Light Stimulus Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Beta-catenin Binding Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Deoxyribonuclease Activity Protein Kinase C Signaling Renal System Process Extracellular Exosome Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Programmed Cell Death Response To UV Regulation Of Intracellular Protein Transport Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of Endodeoxyribonuclease Activity Regulation Of Intracellular Signal Transduction Regulation Of Phospholipid Catabolic Process Cellular Response To Aldosterone
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?