NHERF2 and LPAR2

Number of citations of the paper that reports this interaction (PubMedID 16203867)
58

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NHERF2	LPAR2
Description		NHERF family PDZ scaffold protein 2	lysophosphatidic acid receptor 2
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Plasma Membrane Cell Surface Membrane Endocytic Vesicle Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity	G Protein-coupled Receptor Activity Protein Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of MAPK Cascade
Pathways			G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Schizophrenia ( 23974872) Sphingolipid levels ( 22359512)
Interacting Genes		46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1	7 interacting genes: ARHGEF11 ARHGEF12 ATXN1 GIPC1 NHERF1 NHERF2 TRIP6
Entrez ID		9351	9170
HPRD ID		05946	05487
Ensembl ID		ENSG00000065054	ENSG00000064547
Uniprot IDs		H3BQS0 Q15599	Q9HBW0
PDB IDs		2D11 2HE4 2OCS 4P0C	4P0C
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Regulation Of Signal Transduction Phosphatase Binding Acidic Amino Acid Transport G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Signaling Receptor Binding Renal Phosphate Ion Absorption Rho Protein Signal Transduction G Protein-coupled Receptor Binding Establishment Of Cell Polarity Beta-catenin Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Amino Acid Transport Signal Transduction POZ Domain Binding Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Identical Protein Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Molecular Adaptor Activity Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Intracellular Phosphate Ion Homeostasis Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Establishment Or Maintenance Of Cell Polarity Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Melanin Biosynthetic Process Rho-activating G Protein-coupled Receptor Signaling Pathway Nuclear Inclusion Body Interleukin-1 Receptor Binding Regulation Of Intracellular Signal Transduction Endomembrane System Extracellular Exosome Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport
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