NHERF2 and BRSK2

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid)

		NHERF2	BRSK2
Description		NHERF family PDZ scaffold protein 2	BR serine/threonine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Centrosome Cytoskeleton Perinuclear Region Of Cytoplasm Distal Axon
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity ATPase Binding ATPase Regulator Activity Protein Serine Kinase Activity
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Apoptotic Process Nervous System Development Axonogenesis Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Establishment Of Cell Polarity Actin Cytoskeleton Organization Neuron Differentiation ERAD Pathway Neuron Projection Morphogenesis Regulation Of Axonogenesis Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Synaptic Vesicle Clustering
Pathways
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Gout ( 32238385) Heroin dependence ( 27936112) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1	12 interacting genes: CDC25B CDC25C COPS5 MAGI3 MAPT NHERF1 NHERF2 SCRIB SNX27 TRAF6 VCP WEE1
Entrez ID		9351	9024
HPRD ID		05946	11611
Ensembl ID		ENSG00000065054	ENSG00000174672
Uniprot IDs		H3BQS0 Q15599	A0A140VJF6 B4DLY3 Q8IWQ3
PDB IDs		2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis	Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Establishment Of Cell Polarity Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Protein Modification Process Establishment Or Maintenance Of Cell Polarity G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Inclusion Body Assembly Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Establishment Of Apical/basal Cell Polarity Positive Regulation Of Meiotic Cell Cycle Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Mitotic Cell Cycle Phase Transition Regulation Of Protein Localization To Synapse Cell Cycle Phase Transition Protein Kinase Binding Protein-membrane Adaptor Activity Inner Ear Receptor Cell Stereocilium Organization Cellular Localization Protein Localization To Plasma Membrane Establishment Of Localization In Cell Localization Within Membrane Negative Regulation Of Mitotic Cell Cycle Cytoplasm Regulation Of Catalytic Activity Glutamatergic Synapse Protein Localization To Cell Periphery Immunological Synapse Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Cycle Process Regulation Of Kinase Activity Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?