NHERF2 and ATP2B2

Number of citations of the paper that reports this interaction (PubMedID 11786550)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NHERF2	ATP2B2
Description		NHERF family PDZ scaffold protein 2	ATPase plasma membrane Ca2+ transporting 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendritic Spine Membrane Intracellular Membrane-bounded Organelle Synapse Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Nucleotide Binding P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity PDZ Domain Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Monoatomic Ion Transport Calcium Ion Transport Sensory Perception Of Sound Neuron Differentiation Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction
Pathways			Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Ritodrine Halothane Desflurane Sevoflurane
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Cognitive decline rate in late mild cognitive impairment ( 26252872) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Manganese levels ( 26025379) Metabolite levels ( 19043545)
Interacting Genes		46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1	8 interacting genes: DLG1 DLG2 DLG4 ERBIN NHERF2 PDZD11 PRKCA SNTA1
Entrez ID		9351	491
HPRD ID		05946	00160
Ensembl ID		ENSG00000065054	ENSG00000157087
Uniprot IDs		H3BQS0 Q15599	A0A2U3U055 Q01814
PDB IDs		2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis	Neuromuscular Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Cell Polarity Adherens Junction Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Basolateral Plasma Membrane GMP Kinase Activity Protein Localization To Cell Junction Protein Localization To Membrane GDP Metabolic Process Kinase Binding Postsynaptic Density Membrane Juxtaparanode Region Of Axon Cell Adhesion Cellular Response To Potassium Ion Anchoring Junction Plasma Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Response To Potassium Ion Localization Within Membrane Regulation Of System Process GMP Metabolic Process Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Protein Localization To Cell Periphery Regulation Of Sodium Ion Transmembrane Transport Postsynaptic Density Regulation Of Biological Quality Phosphatase Binding Chemical Synaptic Transmission Synaptic Membrane Lateral Plasma Membrane Neuron Projection Trans-synaptic Signaling Synaptic Signaling Protein-containing Complex Localization Regulation Of Sodium Ion Transport P2Y1 Nucleotide Receptor Binding Intracellular Protein Localization Nucleoside Monophosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Voltage-gated Potassium Channel Complex Nucleoside Diphosphate Metabolic Process Membrane
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