SLC9A3R2 and ABCC4

Number of citations of the paper that reports this interaction (PMID 18045536)
52

Data Source:
BioGRID (pull down)

		SLC9A3R2	ABCC4
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Platelet Dense Granule Membrane
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding	ATP Binding 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Protein Complex Assembly Negative Regulation Of Phosphatidylinositol 3-kinase Signaling	Platelet Degranulation Blood Coagulation Biological_process Response To Organonitrogen Compound Response To Organic Cyclic Compound Platelet Activation Response To Drug Positive Regulation Of Smooth Muscle Cell Proliferation Transmembrane Transport Oxidation-reduction Process
Pathways			ABC-family proteins mediated transport Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Breast cancer ( 17903305) Longevity ( 20834067) Platelet counts ( 22139419) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653)
Protein-Protein Interactions		35 interactors: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDPK1 PDZK1 PIK3CA PLCB3 PODXL PRKACA PTEN PTH1R RDX SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1	5 interactors: ERBB2IP PDZK1 SLC9A3R1 SLC9A3R2 SNTA1
Entrez ID		9351	10257
HPRD ID		05946	05583
Ensembl ID		ENSG00000065054	ENSG00000125257
Uniprot IDs		Q15599	B7Z3Q7 O15439
PDB IDs		2D11 2HE4 2OCS
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Ion Homeostasis Transmembrane Transport Regulation Of Kinase Activity Regulation Of Ion Transport Positive Regulation Of Ion Transport Regulation Of Protein Phosphorylation Homeostatic Process Positive Regulation Of Transport Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Ion Transmembrane Transport Cellular Cation Homeostasis Organic Anion Transport Cellular Ion Homeostasis Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Positive Regulation Of Protein Kinase Activity Blood Circulation Positive Regulation Of Cellular Protein Metabolic Process Anion Transport Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Transport Positive Regulation Of Protein Phosphorylation Sodium-independent Organic Anion Transport Carnitine Transport Cellular Chemical Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Monocarboxylic Acid Transport Sperm Capacitation Anion Transmembrane Transport Regulation Of Cellular Component Organization Sodium Ion Transport Inorganic Anion Transport Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Quaternary Ammonium Group Transport Positive Regulation Of Cytosolic Calcium Ion Concentration	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Ion Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Renal Phosphate Ion Absorption Monocarboxylic Acid Transport Basal Protein Localization Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Negative Regulation Of Peptidyl-cysteine S-nitrosylation Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Protein Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion Oligopeptide Transport Carnitine Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Phosphate Ion Homeostasis Negative Regulation Of Intracellular Signal Transduction Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Organic Anion Transport Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Ventricular Cardiac Muscle Cell Action Potential Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization Regulation Of Membrane Repolarization Regulation Of Excretion Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Positive Regulation Of Protein Targeting To Membrane Monovalent Inorganic Cation Transport
Tagcloud ?			abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters
Tagcloud (Difference) ?			abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters
Tagcloud (Intersection) ?