FKBP1A and TRPC3

Number of citations of the paper that reports this interaction (PMID 15199065)
14

Data Source:
HPRD (in vitro, in vivo)

		FKBP1A	TRPC3
Gene Name		FK506 binding protein 1A, 12kDa	transient receptor potential cation channel, subfamily C, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Terminal Cisterna Membrane Z Disc Sarcoplasmic Reticulum Membrane Axon Terminus Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signal Transducer Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Macrolide Binding FK506 Binding Calcium Channel Inhibitor Activity Enzyme Binding Hsp70 Protein Binding Type I Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Ion Channel Binding SMAD Binding Activin Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein Phosphorylation Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Muscle Contraction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Response To Iron Ion Cytokine-mediated Signaling Pathway Protein Maturation By Protein Folding Response To Caffeine Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Protein Phosphatase Type 2B Activity Regulation Of Protein Localization Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Proliferation T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extracellular Fibril Organization Regulation Of Immune Response Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Heart Trabecula Formation Chaperone-mediated Protein Folding Calcium Ion Transmembrane Transport Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs		Pimecrolimus Tacrolimus Sirolimus (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl-Beta-D-Glucopyranoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-Hydroxy-2-Butanone MYRISTIC ACID (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A DHFR FKBP4 GLMN ITPR1 MID1 MTOR PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1	20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		2280	7222
HPRD ID		01741	15999
Ensembl ID		ENSG00000088832	ENSG00000138741
Uniprot IDs		P62942 Q0VDC6	J3QTB0 Q13507
PDB IDs		1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Transport Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Regulation Of Phosphorylation Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Response To Stress Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Response To Abiotic Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Phosphorylation Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Localization To Nucleus Cell Differentiation Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Intracellular Transport Response To Stimulus Negative Regulation Of Cell Differentiation Activin Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Differentiation Signal Transduction By Phosphorylation Regulation Of Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Chemical Homeostasis	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol
Tagcloud ?			channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Difference) ?			channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Intersection) ?