FKBP1A and DCAF11

Number of citations of the paper that reports this interaction (PubMedID 33783207)
35

Data Source:
BioGRID (far western blotting)

		FKBP1A	DCAF11
Description		FKBP prolyl isomerase 1A	DDB1 and CUL4 associated factor 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex	Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Calcium Channel Regulator Activity Protein Binding Macrolide Binding FK506 Binding Isomerase Activity Signaling Receptor Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Transmembrane Transporter Binding I-SMAD Binding Activin Receptor Binding	Protein Binding
	Biological Process	Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein Maturation Ventricular Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Supramolecular Fiber Organization Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation	Respiratory System Process Response To Oxidative Stress Memory Gene Expression Protein Ubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Cognition
Pathways		mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses	Neddylation
Drugs		Pimecrolimus Tacrolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)
Interacting Genes		31 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DCAF11 DHFR ERBB2 ERBB3 ERBB4 FKBP4 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1	15 interacting genes: AGR2 CDKN1A CRYAA CUL4B DDB1 FKBP1A GPSM1 PTEN RCN1 SLBP TNNI1 TNNI2 TNS2 TRIM55 TRIM63
Entrez ID		2280	80344
HPRD ID		01741	18297
Ensembl ID		ENSG00000088832	ENSG00000100897
Uniprot IDs		A0A087WTS4 P62942 Q0VDC6	B3KSW2 Q59GN6 Q8TEB1
PDB IDs		1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA 6VCU 6YF0 6YF1 6YF2 6YF3 7EPD 7U0T 7U8D 8CHI 8CHJ 8CHK 8CHL 8CHM 8ER6 8ER7 8ERA 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD4 8JGA 8PDF 8POD 8PPZ 8X6P 8XI9 9CHU 9CHV 9CHX
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Positive Regulation Of Multicellular Organismal Process Heart Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Projection Organization Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Cell Development SMAD Binding Regulation Of Developmental Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Ubiquitin Protein Ligase Binding Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process System Development Positive Regulation Of Lamellipodium Assembly Regulation Of Cell Communication Activin Receptor Activity, Type I Regulation Of Signaling Cellular Component Assembly Signal Transduction Regulation Of Cell Differentiation Regulation Of Superoxide Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Regulation Of Supramolecular Fiber Organization Negative Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction	Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Troponin Complex Cellular Response To UV Cul4A-RING E3 Ubiquitin Ligase Complex UV-damage Excision Repair Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Cellular Response To Light Stimulus Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Protein Refolding Cul4-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Phosphate Metabolic Process Molecular Function Inhibitor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Radiation Skeletal Muscle Contraction Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Response To Electrical Stimulus Developmental Process Cardiac Muscle Contraction Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Mitotic Cell Cycle Macrolide Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Catabolic Process Regulation Of System Process Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cell Cycle G1/S Phase Transition PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of Growth Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Damaged DNA Binding Protein Ubiquitination Cytoplasmic Side Of Membrane Regulation Of Muscle System Process Ryanodine Receptor Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
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