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FKBP1A and BMPR1A
Number of citations of the paper that reports this interaction (PubMedID
9663660
)
0
Data Source:
BioGRID
(two hybrid)
FKBP1A
BMPR1A
Description
FKBP prolyl isomerase 1A
bone morphogenetic protein receptor type 1A
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Terminal Cisterna
Membrane
Sarcoplasmic Reticulum
Z Disc
Sarcoplasmic Reticulum Membrane
Cytoplasmic Side Of Membrane
Ryanodine Receptor Complex
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
HFE-transferrin Receptor Complex
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Transforming Growth Factor Beta Receptor Binding
Calcium Channel Regulator Activity
Protein Binding
Macrolide Binding
FK506 Binding
Isomerase Activity
Signaling Receptor Inhibitor Activity
Type I Transforming Growth Factor Beta Receptor Binding
Transmembrane Transporter Binding
I-SMAD Binding
Activin Receptor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
BMP Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
BMP Receptor Activity
Biological Process
Heart Morphogenesis
Protein Folding
'de Novo' Protein Folding
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Localization
Negative Regulation Of Activin Receptor Signaling Pathway
Protein Refolding
T Cell Activation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Immune Response
Protein Maturation
Ventricular Cardiac Muscle Tissue Morphogenesis
Heart Trabecula Formation
Supramolecular Fiber Organization
Regulation Of Amyloid Precursor Protein Catabolic Process
Amyloid Fibril Formation
Angiogenesis
Osteoblast Differentiation
In Utero Embryonic Development
Mesoderm Formation
Somitogenesis
Mullerian Duct Regression
Positive Regulation Of Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Development
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Endocardial Cushion Formation
Intracellular Iron Ion Homeostasis
Immune Response
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Ectoderm Development
Nervous System Development
Endoderm Development
Heart Development
Dorsal/ventral Axis Specification
Anterior/posterior Pattern Specification
Dorsal/ventral Pattern Formation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Cardiac Muscle Cell Apoptotic Process
Neural Crest Cell Development
Negative Regulation Of Smooth Muscle Cell Migration
Central Nervous System Neuron Differentiation
Pituitary Gland Development
Neural Plate Mediolateral Regionalization
Cell Differentiation
Lung Development
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta2 Production
Somatic Stem Cell Population Maintenance
Hindlimb Morphogenesis
Dorsal Aorta Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Development
Paraxial Mesoderm Structural Organization
Lateral Mesoderm Development
Regulation Of Lateral Mesodermal Cell Fate Specification
Mesendoderm Development
Embryonic Organ Development
Developmental Growth
Embryonic Morphogenesis
Stem Cell Differentiation
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Neurogenesis
Negative Regulation Of Muscle Cell Differentiation
Cartilage Development
Roof Of Mouth Development
Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Neural Plate Pattern Specification
Heart Formation
Atrioventricular Node Cell Development
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Dendrite Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Cardiac Ventricle Development
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Fibrous Ring Of Heart Morphogenesis
Regulation Of Neural Crest Cell Differentiation
Anti-Mullerian Hormone Receptor Signaling Pathway
Regulation Of Cellular Senescence
Pathways
mTORC1-mediated signalling
Calcineurin activates NFAT
Calcineurin activates NFAT
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR1 LBD Mutants in Cancer
Potential therapeutics for SARS
SARS-CoV-1 activates/modulates innate immune responses
Signaling by BMP
Drugs
Pimecrolimus
Tacrolimus
(3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
Gpi-1046
Methyl Methylsulfinylmethyl Sulfide
FKB-001
Heptyl glucoside
L-709,587
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
4-hydroxybutan-2-one
GPI-1485
Myristic acid
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
Dorsomorphin
Dibotermin alfa
Diseases
Juvenile polyposis syndrome
Hereditary mixed polyposis syndrome
GWAS
Estimated glomerular filtration rate (
31152163
)
Apolipoprotein A1 levels (
32203549
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
White blood cell count (
32888494
)
Interacting Genes
31 interacting genes:
ABI2
ACVR1B
ACVRL1
AHSP
APP
BARD1
BMPR1A
CDC42
DCAF11
DHFR
ERBB2
ERBB3
ERBB4
FKBP4
GLMN
HSP90AA1
ITPR1
MAPT
MDM2
MID1
MTOR
NLGN3
PPP3CA
RYR1
RYR3
SF3B4
TGFB1
TGFB1I1
TGFBR1
TRPC3
YY1
45 interacting genes:
ACVR1
ALDOB
AOPEP
BAMBI
BMP2
BMP4
BMP5
BMP6
BMP7
BMPR1B
BMPR2
CDK8
CRIPTO
CTSV
FANCC
FBP1
FBP2
FKBP1A
FKBP1B
GALNT12
GDF5
GDF6
GDF9
HOXC8
HRAS
IGFBP3
MAP2K1
MSANTD3
NEDD4
NEDD4L
OTUB1
RASA1
SEC61B
SF3B4
SFRP2
SFRP4
SMAD1
TAB1
TGFB1
TGFBRAP1
TRMO
USP15
XPA
ZMYND11
ZNF189
Entrez ID
2280
657
HPRD ID
01741
03192
Ensembl ID
ENSG00000088832
ENSG00000107779
Uniprot IDs
A0A087WTS4
P62942
Q0VDC6
P36894
PDB IDs
1A7X
1B6C
1BKF
1BL4
1D6O
1D7H
1D7I
1D7J
1EYM
1F40
1FAP
1FKB
1FKD
1FKF
1FKG
1FKH
1FKI
1FKJ
1FKR
1FKS
1FKT
1J4H
1J4I
1J4R
1NSG
1QPF
1QPL
2DG3
2DG4
2DG9
2FAP
2FKE
2ND5
2PPN
2PPO
2PPP
2RSE
3FAP
3H9R
3MDY
4DH0
4FAP
4IPX
4N19
4ODP
4ODQ
4ODR
5I7P
5I7Q
6I1S
6M4U
6OQA
6VCU
6YF0
6YF1
6YF2
6YF3
7EPD
7U0T
7U8D
8CHI
8CHJ
8CHK
8CHL
8CHM
8ER6
8ER7
8ERA
8JCU
8JCV
8JCW
8JCX
8JCY
8JCZ
8JD0
8JD1
8JD2
8JD4
8JGA
8PDF
8POD
8PPZ
8X6P
8XI9
9CHU
9CHV
9CHX
1ES7
1REW
2GOO
2H62
2H64
2K3G
2QJ9
2QJA
2QJB
3NH7
3QB4
Enriched GO Terms of Interacting Partners
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Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Growth
Positive Regulation Of Multicellular Organismal Process
Heart Development
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Developmental Process
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Multicellular Organismal Process
Regulation Of Intracellular Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Positive Regulation Of Cell Communication
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Regulation Of Cell Projection Organization
Regulation Of Calcium-mediated Signaling
Positive Regulation Of Cell Differentiation
Cell Development
SMAD Binding
Regulation Of Developmental Process
Regulation Of Cell Growth
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Cellular Component Organization
Transforming Growth Factor Beta Receptor Activity, Type I
Receptor Complex
Ubiquitin Protein Ligase Binding
Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Developmental Process
System Development
Positive Regulation Of Lamellipodium Assembly
Regulation Of Cell Communication
Activin Receptor Activity, Type I
Regulation Of Signaling
Cellular Component Assembly
Signal Transduction
Regulation Of Cell Differentiation
Regulation Of Superoxide Metabolic Process
Negative Regulation Of Cell Differentiation
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Growth
Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Regulation Of Cartilage Development
Positive Regulation Of Signal Transduction
Cellular Response To BMP Stimulus
Regulation Of Osteoblast Differentiation
Transforming Growth Factor Beta Receptor Signaling Pathway
Growth Factor Activity
Cartilage Development
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Bone Mineralization
Positive Regulation Of Intracellular Signal Transduction
Osteoblast Differentiation
Positive Regulation Of Biomineral Tissue Development
BMP Receptor Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Ossification
Anatomical Structure Morphogenesis
Regulation Of Signal Transduction
Positive Regulation Of Cell Differentiation
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Ossification
Regulation Of Bone Mineralization
Positive Regulation Of Developmental Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Population Proliferation
Cytokine Activity
Regulation Of Primary Metabolic Process
Pattern Specification Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Animal Organ Morphogenesis
Response To Growth Factor
Mesenchyme Development
Positive Regulation Of Epithelial To Mesenchymal Transition
Endocardial Cushion Formation
Signal Transduction
Regulation Of RNA Metabolic Process
Heart Development
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Tagcloud (Intersection)
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