FKBP1A and BARD1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		FKBP1A	BARD1
Description		FKBP prolyl isomerase 1A	BRCA1 associated RING domain 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex BRCA1-B Complex BRCA1-C Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Calcium Channel Regulator Activity Protein Binding Macrolide Binding FK506 Binding Isomerase Activity Signaling Receptor Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Transmembrane Transporter Binding I-SMAD Binding Activin Receptor Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity
	Biological Process	Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein Maturation Ventricular Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Supramolecular Fiber Organization Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation	Tissue Homeostasis DNA Repair Regulation Of DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Homologous Recombination Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Protein K6-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways		mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		Pimecrolimus Tacrolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 21124317 22941191) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)
Interacting Genes		31 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DCAF11 DHFR ERBB2 ERBB3 ERBB4 FKBP4 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1	131 interacting genes: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 AXIN2 BCCIP BCL3 BGLT3 BRCA1 BRD7 CAP1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCAF8L2 DCC DDX39B DNAI7 ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AC4 H2BC3 H3C1 HAP1 HNRNPC HNRNPLL HSF2BP HSPA14 IDI1 IKZF1 ING5 KAT5 KAT7 KBTBD7 KIFC3 KRT40 LARP7 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A MTUS2 NFKB1 NFKBIA NPC2 PCBP2 PDXK PDZD8 PIAS1 PIAS4 PIN1 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RABEP1 RAD51 RBBP8 RBMY2BP RNF10 RPS20 SELENBP1 SETDB1 SKIC8 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WRN XRCC6 ZFP64 ZHX1 ZNF121 ZNF655
Entrez ID		2280	580
HPRD ID		01741	03354
Ensembl ID		ENSG00000088832	ENSG00000138376
Uniprot IDs		A0A087WTS4 P62942 Q0VDC6	A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728
PDB IDs		1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA 6VCU 6YF0 6YF1 6YF2 6YF3 7EPD 7U0T 7U8D 8CHI 8CHJ 8CHK 8CHL 8CHM 8ER6 8ER7 8ERA 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD4 8JGA 8PDF 8POD 8PPZ 8X6P 8XI9 9CHU 9CHV 9CHX	1JM7 2NTE 2R1Z 3C5R 3FA2 6M14 7E8I 7JZV 7LYB 7LYC 8GRQ
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Positive Regulation Of Multicellular Organismal Process Heart Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Projection Organization Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Cell Development SMAD Binding Regulation Of Developmental Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Ubiquitin Protein Ligase Binding Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process System Development Positive Regulation Of Lamellipodium Assembly Regulation Of Cell Communication Activin Receptor Activity, Type I Regulation Of Signaling Cellular Component Assembly Signal Transduction Regulation Of Cell Differentiation Regulation Of Superoxide Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Regulation Of Supramolecular Fiber Organization Negative Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction	DNA Damage Response Nucleoplasm DNA Repair Ubiquitin Conjugating Enzyme Activity DNA Metabolic Process Chromosome Nucleus Chromatin Organization Nucleic Acid Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Protein K48-linked Ubiquitination Double-strand Break Repair Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Enzyme Binding Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Maintenance Of DNA Repeat Elements Heterochromatin Formation Negative Regulation Of DNA Recombination Chromatin Binding Protein Monoubiquitination Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Single Guanine Insertion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression, Epigenetic
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