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FKBP1A and ACVRL1
Number of citations of the paper that reports this interaction (PMID
19592636
)
9
Data Source:
BioGRID
(two hybrid)
FKBP1A
ACVRL1
Gene Name
FK506 binding protein 1A, 12kDa
activin A receptor type II-like 1
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Terminal Cisterna
Membrane
Z Disc
Sarcoplasmic Reticulum Membrane
Axon Terminus
Extracellular Vesicular Exosome
Integral Component Of Plasma Membrane
Cell Surface
Dendrite
Neuronal Cell Body
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Signal Transducer Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Macrolide Binding
FK506 Binding
Calcium Channel Inhibitor Activity
Enzyme Binding
Hsp70 Protein Binding
Type I Transforming Growth Factor Beta Receptor Binding
Protein Homodimerization Activity
Ion Channel Binding
SMAD Binding
Activin Binding
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Protein Kinase Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Biological Process
Protein Peptidyl-prolyl Isomerization
Negative Regulation Of Protein Phosphorylation
Heart Morphogenesis
Protein Folding
'de Novo' Protein Folding
Muscle Contraction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Response To Iron Ion
Cytokine-mediated Signaling Pathway
Protein Maturation By Protein Folding
Response To Caffeine
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Binding
Negative Regulation Of Protein Phosphatase Type 2B Activity
Regulation Of Protein Localization
Regulation Of Activin Receptor Signaling Pathway
Protein Refolding
T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Extracellular Fibril Organization
Regulation Of Immune Response
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Heart Trabecula Formation
Chaperone-mediated Protein Folding
Calcium Ion Transmembrane Transport
Regulation Of Amyloid Precursor Protein Catabolic Process
Amyloid Fibril Formation
Angiogenesis
In Utero Embryonic Development
Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Maturation
Blood Vessel Remodeling
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Negative Regulation Of Cell Adhesion
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Blood Circulation
Regulation Of Blood Pressure
Negative Regulation Of Cell Proliferation
Negative Regulation Of Endothelial Cell Migration
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Signal Transduction By Phosphorylation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Heterooligomerization
Negative Regulation Of Focal Adhesion Assembly
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Endothelial Tube Morphogenesis
Retina Vasculature Development In Camera-type Eye
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Negative Regulation Of DNA Biosynthetic Process
Pathways
Loss of Function of TGFBR2 in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Pimecrolimus
Tacrolimus
Sirolimus
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
Gpi-1046
Methyl Methylsulfinylmethyl Sulfide
FKB-001
Heptyl-Beta-D-Glucopyranoside
L-709,587
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
4-Hydroxy-2-Butanone
MYRISTIC ACID
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Adenosine triphosphate
Diseases
GWAS
Urate levels (
23263486
)
Protein-Protein Interactions
21 interactors:
ACVR1B
ACVRL1
AHSP
APP
BARD1
BMPR1A
DHFR
FKBP4
GLMN
ITPR1
MID1
MTOR
PPP3CA
RYR1
RYR3
SF3B4
TGFB1
TGFB1I1
TGFBR1
TRPC3
YY1
12 interactors:
ACVR2A
BAMBI
CSNK2B
FKBP1A
SMAD1
SNX6
TGFB1
TGFB3
TGFBR1
TGFBR2
TGFBRAP1
XIAP
Entrez ID
2280
94
HPRD ID
01741
03181
Ensembl ID
ENSG00000088832
ENSG00000139567
Uniprot IDs
P62942
Q0VDC6
E7EN07
P37023
PDB IDs
1A7X
1B6C
1BKF
1BL4
1D6O
1D7H
1D7I
1D7J
1EYM
1F40
1FAP
1FKB
1FKD
1FKF
1FKG
1FKH
1FKI
1FKJ
1FKR
1FKS
1FKT
1J4H
1J4I
1J4R
1NSG
1QPF
1QPL
2DG3
2DG4
2DG9
2FAP
2FKE
2PPN
2PPO
2PPP
2RSE
3FAP
3H9R
3MDY
4DH0
4FAP
4IPX
2LCR
3MY0
4FAO
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
Response To Organic Substance
Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Transport
Developmental Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Multicellular Organismal Development
Regulation Of Phosphorylation
Regulation Of Establishment Of Protein Localization
Regulation Of Intracellular Transport
Response To Stress
Regulation Of Intracellular Protein Transport
Regulation Of Cellular Localization
Response To Abiotic Stimulus
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Protein Localization
Positive Regulation Of SMAD Protein Import Into Nucleus
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Phosphorylation
Regulation Of SMAD Protein Import Into Nucleus
Positive Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Regulation Of Protein Localization To Nucleus
Cell Differentiation
Regulation Of Gene Expression
Anatomical Structure Development
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Cellular Response To Organic Substance
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Intracellular Transport
Response To Stimulus
Negative Regulation Of Cell Differentiation
Activin Receptor Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Cell Differentiation
Signal Transduction By Phosphorylation
Regulation Of Metabolic Process
Regulation Of Epithelial Cell Proliferation
Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Cellular Chemical Homeostasis
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Cellular Response To Growth Factor Stimulus
Cellular Response To Organic Substance
Positive Regulation Of Protein Modification Process
Cell Surface Receptor Signaling Pathway
Regulation Of Catalytic Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Regulation Of Epithelial To Mesenchymal Transition
SMAD Protein Complex Assembly
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of SMAD Protein Import Into Nucleus
Regulation Of SMAD Protein Import Into Nucleus
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Regulation Of Cell Proliferation
Regulation Of Phosphorus Metabolic Process
Regulation Of Binding
Positive Regulation Of Ossification
Positive Regulation Of Protein Import Into Nucleus
Skeletal System Development
Response To Cholesterol
Signal Transduction By Phosphorylation
Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Nucleocytoplasmic Transport
Negative Regulation Of Cell Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Protein Phosphorylation
Signal Transduction
Tagcloud
?
a1cf
activins
ancestry
atxn2
b3gnt4
baz1b
consortium
excretion
fractional
gout
gugc
hlf
hnf4g
implicate
inhbb
inhibins
maf
nfat5
painful
prkag2
replicated
sfmbt1
stc1
tmem171
trim46
ube2q2
urate
vegfa
Tagcloud (Difference)
?
a1cf
activins
ancestry
atxn2
b3gnt4
baz1b
consortium
excretion
fractional
gout
gugc
hlf
hnf4g
implicate
inhbb
inhibins
maf
nfat5
painful
prkag2
replicated
sfmbt1
stc1
tmem171
trim46
ube2q2
urate
vegfa
Tagcloud (Intersection)
?