FKBP1A and ACVRL1

Number of citations of the paper that reports this interaction (PubMedID 19592636)
52

Data Source:
BioGRID (two hybrid)

		FKBP1A	ACVRL1
Description		FKBP prolyl isomerase 1A	activin A receptor like type 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex	Plasma Membrane Cell Surface Membrane BMP Receptor Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Calcium Channel Regulator Activity Protein Binding Macrolide Binding FK506 Binding Isomerase Activity Signaling Receptor Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Transmembrane Transporter Binding I-SMAD Binding Activin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity
	Biological Process	Heart Morphogenesis Protein Folding 'de Novo' Protein Folding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein Maturation Ventricular Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Supramolecular Fiber Organization Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation	Angiogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of DNA-templated Transcription Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of SMAD Protein Signal Transduction Epithelial Tube Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Circulatory System Development Endocardial Cushion To Mesenchymal Transition Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Multicellular Organismal Development
Pathways		mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses	Signaling by BMP
Drugs		Pimecrolimus Tacrolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin	ATP
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Estimated glomerular filtration rate ( 31152163)	Appendicular lean mass ( 33097823) Hematocrit ( 29403010) Hemoglobin ( 32888494 29403010) Hemoglobin levels ( 32327693) Lymphocyte count ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Urate levels ( 23263486) White blood cell count ( 27863252 32888494)
Interacting Genes		31 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DCAF11 DHFR ERBB2 ERBB3 ERBB4 FKBP4 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1	15 interacting genes: ACVR2A BAMBI CSNK2B EIF4E FKBP1A GDF2 RNF31 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP
Entrez ID		2280	94
HPRD ID		01741	03181
Ensembl ID		ENSG00000088832	ENSG00000139567
Uniprot IDs		A0A087WTS4 P62942 Q0VDC6	A0A0S2Z2Y4 A0A0S2Z310 H3BTZ2 P37023
PDB IDs		1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA 6VCU 6YF0 6YF1 6YF2 6YF3 7EPD 7U0T 7U8D 8CHI 8CHJ 8CHK 8CHL 8CHM 8ER6 8ER7 8ERA 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD4 8JGA 8PDF 8POD 8PPZ 8X6P 8XI9 9CHU 9CHV 9CHX	2LCR 3MY0 4FAO 6SF1 6SF2 6SF3 7PPC
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Growth Positive Regulation Of Multicellular Organismal Process Heart Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Developmental Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Projection Organization Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Cell Development SMAD Binding Regulation Of Developmental Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Ubiquitin Protein Ligase Binding Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process System Development Positive Regulation Of Lamellipodium Assembly Regulation Of Cell Communication Activin Receptor Activity, Type I Regulation Of Signaling Cellular Component Assembly Signal Transduction Regulation Of Cell Differentiation Regulation Of Superoxide Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Regulation Of Supramolecular Fiber Organization Negative Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction	Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cellular Response To Growth Factor Stimulus Type II Transforming Growth Factor Beta Receptor Binding Response To Growth Factor Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Type III Transforming Growth Factor Beta Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Activin Receptor Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation I-SMAD Binding Positive Regulation Of Vasculature Development Regulation Of Cartilage Development Regulation Of Signal Transduction Transforming Growth Factor Beta Binding Tissue Morphogenesis Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Response To Cholesterol Regulation Of Activin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Gland Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Cell Differentiation Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Multicellular Organismal Process Langerhans Cell Differentiation
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