NID2 and COL4A1

Number of citations of the paper that reports this interaction (PMID 9733643)
43

Data Source:
BioGRID (pull down)

		NID2	COL4A1
Gene Name		nidogen 2 (osteonidogen)	collagen, type IV, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Cell Surface Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Collagen Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Extracellular Matrix Organization Basement Membrane Organization	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		Laminin interactions	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Pulmonary function ( 17903307)	Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: COL13A1 COL1A1 COL4A1 ELN HSPG2 KRTAP10-3 LAMC1 PRELP SKIL	27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1
Entrez ID		22795	1282
HPRD ID		05654	00359
Ensembl ID		ENSG00000087303	ENSG00000187498
Uniprot IDs		Q14112	P02462
PDB IDs			1LI1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endochondral Ossification Anatomical Structure Morphogenesis System Development Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Development Multicellular Organismal Metabolic Process Anatomical Structure Development Tissue Development Protein Heterotrimerization Bone Morphogenesis Developmental Process Skeletal System Development Bone Development Protein Trimerization Cartilage Development Involved In Endochondral Bone Morphogenesis Skeletal System Morphogenesis Ossification Organ Development Catabolic Process Striated Muscle Tissue Development Muscle Tissue Development Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Cell Differentiation Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Fluoride Glycosaminoglycan Biosynthetic Process Blood Vessel Development Vasculature Development Response To Amino Acid Tooth Eruption Response To Fluoride Protein Heterooligomerization Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Embryonic Skeletal System Development Cellular Response To Acid Chemical Glycosaminoglycan Metabolic Process Retinal Blood Vessel Morphogenesis Cellular Response To Vitamin E Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?			arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Difference) ?			arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Intersection) ?