NID2 and LAMC1

Number of citations: 0 (PubMedID 9733643)
Data Source: HPRD (in vitro)

		NID2	LAMC1
Name		nidogen 2	laminin subunit gamma 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Plasma Membrane Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Basement Membrane Organization	Cell Adhesion Endoderm Development Tissue Development Cell Migration Extracellular Matrix Disassembly Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Positive Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Muscle Cell Differentiation Protein-containing Complex Assembly Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Laminin interactions Laminin interactions	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs		None	Lanoteplase
GWAS		Age-related hearing impairment ( 34108613 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 28892062 ) Craniofacial microsomia ( 26853712 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels ( 32203549 ) Hip index ( 34021172 ) Lung cancer (smoking interaction) ( 24658283 ) Pulmonary function ( 17903307 ) Triglyceride levels ( 32203549 29403010 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for body mass index ( 26785701 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Clozapine-induced agranulocytosis ( 25187353 ) Colorectal cancer ( 23266556 ) Colorectal cancer or advanced adenoma ( 30510241 ) Diastolic blood pressure ( 30224653 ) Fuchs's corneal dystrophy ( 28358029 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) Hypertriglyceridemia ( 27599772 ) LDL cholesterol levels in HIV infection ( 33109212 ) Red blood cell count ( 32888494 ) Systemic lupus erythematosus ( 24871463 )
Novel Interactors		3 novel interactors: KCNJ1 POLE2 TNFRSF14	None recorded
Interacting Genes		24 interacting genes: ANKRD13D CCN3 COL13A1 COL1A1 COL4A1 ELN GNE HOXC8 HSPG2 KPRP KRTAP1-3 KRTAP10-3 KRTAP6-2 LAMC1 LCE1A MAML3 PITX1 PLSCR4 RBP3 SKIL TFG UNKL ZNF581 ZNF774	17 interacting genes: ANTXR2 APP ATF7IP CENPU FILNC1 KEAP1 LAMA5 NID1 NID2 SMARCA2 SNAPIN SNX2 SRPK1 TANK UBC WASHC3 WEE2-AS1
Entrez ID		22795	3915
HPRD ID		05654	01030
Ensembl ID		ENSG00000087303	ENSG00000135862
Uniprot IDs		Q14112	P11047 Q6NVY8
PDB IDs		Not available	5XAU 7CEC 8DMK
GO Terms Enriched among Interactors		Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Structural Constituent Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Tissue Development Platelet-derived Growth Factor Binding Extracellular Matrix Constituent Conferring Elasticity Skeletal Muscle Tissue Development Collagen Trimer Collagen-activated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Circulatory System Development	Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Extracellular Matrix Structural Constituent Insulin Receptor Binding