RING1 and PHC1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		RING1	PHC1
Description		ring finger protein 1	polyhomeotic homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Camera-type Eye Morphogenesis	Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Asthma ( 32296059) Wegener's granulomatosis ( 23740775)	Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 GRSF1 H2AC4 H3-4 NFKBID OGT PCGF3 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K ZIM3	25 interacting genes: BMI1 CRYAA FAM9A GMNN HSPA8 PCGF3 PHC2 PIAS2 PPIL3 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7
Entrez ID		6015	1911
HPRD ID		03624	16009
Ensembl ID		ENSG00000204227	ENSG00000111752
Uniprot IDs		A0A1U9X8F2 Q06587	P78364 Q6GMQ3
PDB IDs			2L8E
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Modification Process Nucleoplasm Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Primary Metabolic Process Heterochromatin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Carbohydrate Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle G1/S Phase Transition RING-like Zinc Finger Domain Binding Regulation Of Phosphorus Metabolic Process Transferase Activity Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Purine Nucleotide Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition	PRC1 Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription PcG Protein Complex Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Nuclear Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Regulation Of Macromolecule Metabolic Process Transcription Factor Binding Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Corepressor Activity Histone H2AK119 Ubiquitin Ligase Activity Post-translational Protein Modification Small Protein Activating Enzyme Binding Nuclear Speck Nucleolus Epigenetic Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Sex Chromatin PML Body Organization Regulation Of Primary Metabolic Process Protein Modification Process Heterochromatin Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Intracellular Transport Histone Binding Chromatin Organization Regulation Of Protein Stability Zinc Ion Binding Protein Tag Activity Chromatin Remodeling Nuclear Body Organization Protein Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?