RING1 and CBX4

Number of citations of the paper that reports this interaction (PubMedID 9199346)
43

Data Source:
HPRD (in vivo, two hybrid)

		RING1	CBX4
Description		ring finger protein 1	chromobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	Transcription Cis-regulatory Region Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Transferase Activity SUMO Transferase Activity Enzyme Binding SUMO Binding Phosphoprotein Binding SUMO Ligase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Camera-type Eye Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Asthma ( 32296059) Wegener's granulomatosis ( 23740775)	Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		33 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 GRSF1 H2AC4 H3-4 NFKBID OGT PCGF3 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K ZIM3	28 interacting genes: ARID3C CBS CHD3 CREBBP CTBP1 CTBP2 FHL1 H3-3A H3-4 H3C1 H3C14 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP STIP1 SUV39H1 TRIM21 UBE2I ZBED1 ZEB2
Entrez ID		6015	8535
HPRD ID		03624	04357
Ensembl ID		ENSG00000204227	ENSG00000141582
Uniprot IDs		A0A1U9X8F2 Q06587	A0A0S2Z5B2 O00257
PDB IDs			2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Modification Process Nucleoplasm Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Primary Metabolic Process Heterochromatin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Carbohydrate Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle G1/S Phase Transition RING-like Zinc Finger Domain Binding Regulation Of Phosphorus Metabolic Process Transferase Activity Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Purine Nucleotide Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition	Chromatin Remodeling Nucleus Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II PML Body Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RING-like Zinc Finger Domain Binding DNA Binding Chromosome Structural Constituent Of Chromatin Protein-DNA Complex Assembly Zinc Ion Binding Nucleosome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Centromere Complex Assembly Nucleosome Transcription Coregulator Binding Identical Protein Binding Sex Chromatin Nucleosome Organization Positive Regulation Of RNA Metabolic Process Heterochromatin Formation Heterochromatin Transcription Coactivator Activity Unmethylated CpG Binding Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Chromatin
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?