RING1 and FBXO38

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RING1	FBXO38
Description		ring finger protein 1	F-box protein 38
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Nucleus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Camera-type Eye Morphogenesis	Adaptive Immune Response Immune System Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Neuron Projection Development Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Protein K48-linked Ubiquitination
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Asthma ( 32296059) Wegener's granulomatosis ( 23740775)	Chronic obstructive pulmonary disease ( 33909500) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Lung function (FEV1/FVC) ( 31453325) Lung function (FEV1/FVC) variance ( 31453325) Mean reticulocyte volume ( 32888494) Periodontal microbiota ( 22699663) Zinc levels ( 26025379)
Interacting Genes		33 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 GRSF1 H2AC4 H3-4 NFKBID OGT PCGF3 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K ZIM3	9 interacting genes: ABL2 APP CREBBP KLF7 PPM1G RING1 SOX30 SUMO2 USP7
Entrez ID		6015	81545
HPRD ID		03624	09775
Ensembl ID		ENSG00000204227	ENSG00000145868
Uniprot IDs		A0A1U9X8F2 Q06587	Q6AZE0 Q6PIJ6
PDB IDs
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Modification Process Nucleoplasm Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Primary Metabolic Process Heterochromatin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Carbohydrate Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle G1/S Phase Transition RING-like Zinc Finger Domain Binding Regulation Of Phosphorus Metabolic Process Transferase Activity Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Purine Nucleotide Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition	Protein Modification Process Positive Regulation Of T Cell Migration Positive Regulation Of Lymphocyte Migration Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Negative Regulation Of Cell Communication Protein Metabolic Process Negative Regulation Of Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of RNA Metabolic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Amylin Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Post-translational Protein Modification P53 Binding Positive Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Regulation Of Protein Localization Positive Regulation Of DNA-templated Transcription Nuclear Body Nucleoplasm Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Lipoprotein Particle Positive Regulation Of Protein Import Histone H3K27 Acetyltransferase Activity Proacrosomal Vesicle Fusion Positive Regulation Of Mononuclear Cell Migration Regulation Of Metabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process
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