RING1 and PCGF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RING1	PCGF3
Description		ring finger protein 1	polycomb group ring finger 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	X Chromosome Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Camera-type Eye Morphogenesis	Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Asthma ( 32296059) Wegener's granulomatosis ( 23740775)	Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 22443383) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 33169155) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 30297969 32499647) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)
Interacting Genes		33 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 GRSF1 H2AC4 H3-4 NFKBID OGT PCGF3 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K ZIM3	11 interacting genes: BMI1 DZIP3 HNRNPK PHC1 PHC2 RING1 TRIM55 TRIM63 TRIM9 UBE2C UBE2D3
Entrez ID		6015	10336
HPRD ID		03624	11515
Ensembl ID		ENSG00000204227	ENSG00000185619
Uniprot IDs		A0A1U9X8F2 Q06587	B3KQ06 B3KWT8 B4DTN5 Q3KNV8
PDB IDs
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Modification Process Nucleoplasm Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Primary Metabolic Process Heterochromatin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Carbohydrate Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle G1/S Phase Transition RING-like Zinc Finger Domain Binding Regulation Of Phosphorus Metabolic Process Transferase Activity Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Purine Nucleotide Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition	PRC1 Complex Ubiquitin Protein Ligase Activity PcG Protein Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Zinc Ion Binding Sex Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-protein Transferase Activator Activity Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Chromatin Binding Ubiquitin Conjugating Enzyme Activity Protein K11-linked Ubiquitination Metal Ion Binding Heterochromatin Negative Regulation Of Metabolic Process Chromatin Remodeling Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Regulation Of Adaxial/abaxial Pattern Formation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Biosynthetic Process Nuclear Body Chromatin Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Positive Regulation Of Protein Ubiquitination Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Exit From Mitosis Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Nucleus Response To Glucocorticoid Proteasomal Protein Catabolic Process
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