FGG and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		FGG	VKORC1
Description		fibrinogen gamma chain	vitamin K epoxide reductase complex subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Cell-matrix Adhesion Blood Coagulation Hemostasis Protein Secretion Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways		Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Metabolism of vitamin K
Drugs		Alteplase Sucralfate Thrombin Human thrombin Thrombin alfa	Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia	Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Activated partial thromboplastin time ( 29403010) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Fibrinogen levels ( 26561523) Glycine levels ( 30837465) Prothrombin time ( 29403010) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 30659681 31420334 31676865)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		13 interacting genes: APP F13A1 F13B FGA FGB ICAM1 ITGA2B ITGAM ITGB3 SERPINA5 VKORC1 VTN VWF	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		2266	79001
HPRD ID		00621	10540
Ensembl ID		ENSG00000171557	ENSG00000167397
Uniprot IDs		A0A140VJJ6 P02679	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS 4B60	6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Fibrin Clot Formation Coagulation Blood Coagulation Hemostasis Platelet Alpha Granule Protein Activation Cascade Regulation Of Body Fluid Levels Cell-substrate Adhesion External Side Of Plasma Membrane Cell-matrix Adhesion Integrin Binding Platelet Alpha Granule Lumen Cell Adhesion Extracellular Space Extracellular Matrix Negative Regulation Of Endothelial Cell Apoptotic Process Blood Microparticle Regulation Of Endothelial Cell Apoptotic Process Extracellular Exosome Cell Surface Platelet Activation Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Integrin-mediated Signaling Pathway Cell-cell Adhesion Integrin Complex Cell Adhesion Mediated By Integrin Regulation Of ERK1 And ERK2 Cascade Regulation Of Vesicle-mediated Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extracellular Matrix Structural Constituent Extracellular Matrix Binding Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Positive Regulation Of Cell-substrate Adhesion Protein Maturation Positive Regulation Of Leukocyte Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Extrinsic Apoptotic Signaling Pathway Induction Of Bacterial Agglutination Negative Regulation Of Blood Coagulation Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinogen Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Antibacterial Humoral Response Homotypic Cell-cell Adhesion Positive Regulation Of MAPK Cascade	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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