FGG and F13B

Number of citations of the paper that reports this interaction (PMID 8756701)
11

Data Source:
HPRD (in vitro)

		FGG	F13B
Gene Name		fibrinogen gamma chain	coagulation factor XIII, B polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region
	Molecular Function	Receptor Binding Structural Molecule Activity Protein Binding, Bridging Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Blood Coagulation
Pathways		p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	Common Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 23650146)	Age-related macular degeneration ( 23536807) Erectile dysfunction ( 22704111)
Protein-Protein Interactions		10 interactors: F13A1 F13B FGA FGB ICAM1 ITGAM ITGB3 SERPINA5 VKORC1 VTN	2 interactors: F13A1 FGG
Entrez ID		2266	2165
HPRD ID		00621	00605
Ensembl ID		ENSG00000171557	ENSG00000143278
Uniprot IDs		P02679	P05160
PDB IDs		1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Platelet Degranulation Cell Activation Homotypic Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasoconstriction Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Cell-matrix Adhesion Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Single Organismal Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Vasoconstriction Cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Exocytosis Innate Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Secretion By Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune System Process Secretion Immune Response Leukocyte Migration Regulation Of Phosphorylation Defense Response	Platelet Degranulation Platelet Activation Exocytosis Blood Coagulation Hemostasis Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Positive Regulation Of Heterotypic Cell-cell Adhesion Cell Activation Response To Wounding Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Peptide Cross-linking Vesicle-mediated Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Establishment Of Localization In Cell Protein Polymerization Positive Regulation Of Hormone Secretion Response To Calcium Ion Positive Regulation Of Cell-substrate Adhesion Cellular Localization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Exocytosis
Tagcloud ?		apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic gc geographic jekaterinburg krakow moscow olomouc plg polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Difference) ?		apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic gc geographic jekaterinburg krakow moscow olomouc plg polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Intersection) ?