FGG and VWF

Data Source:
BioGRID (pull down)

		FGG	VWF
Description		fibrinogen gamma chain	von Willebrand factor
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endoplasmic Reticulum Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Weibel-Palade Body Extracellular Exosome Cell Periphery
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Immunoglobulin Binding Identical Protein Binding Protein-folding Chaperone Binding
	Biological Process	Cell-matrix Adhesion Blood Coagulation Hemostasis Protein Secretion Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Cell Adhesion Blood Coagulation Hemostasis Response To Wounding Platelet Activation Cell-substrate Adhesion Positive Regulation Of Intracellular Signal Transduction
Pathways		Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V
Drugs		Alteplase Sucralfate Thrombin Human thrombin Thrombin alfa	Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic factor (recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol Rurioctocog alfa pegol
Diseases		Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Activated partial thromboplastin time ( 29403010) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Fibrinogen levels ( 26561523) Glycine levels ( 30837465) Prothrombin time ( 29403010) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 30659681 31420334 31676865)	Coagulation factor levels ( 23267103) Factor VIII levels ( 20231535 30586737) Low vWF levels ( 26486471) Mean platelet volume ( 22139419 27863252 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 22139419 26805783 32888494) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) vWF levels in ischaemic stroke and hyperhomocysteinaemia ( 28495826)
Interacting Genes		13 interacting genes: APP F13A1 F13B FGA FGB ICAM1 ITGA2B ITGAM ITGB3 SERPINA5 VKORC1 VTN VWF	28 interacting genes: ADAMTS13 ALB APOA1 ATXN7 CACNA1A CALR COL1A1 COL1A2 COL3A1 F8 FGA FGB FGG FURIN FXR1 GP1BA HOXA1 HSPA5 ITGA2B LCOR MAP3K3 NUFIP2 P4HB PROS1 RAC1 SOCS4 TNFRSF11B ZNF512B
Entrez ID		2266	7450
HPRD ID		00621	01906
Ensembl ID		ENSG00000171557	ENSG00000110799
Uniprot IDs		A0A140VJJ6 P02679	P04275
PDB IDs		1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS 4B60	1AO3 1ATZ 1AUQ 1FE8 1FNS 1IJB 1IJK 1M10 1OAK 1SQ0 1U0N 1UEX 2ADF 2MHP 2MHQ 3GXB 3HXO 3HXQ 3PPV 3PPW 3PPX 3PPY 3ZQK 4C29 4C2A 4C2B 4DMU 4NT5 5BV8 6FWN 6N29 7EOW 7F49 7KWO 7P4N 7PMV 7PNF 7ZWH 8D3C 8D3D
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Fibrin Clot Formation Coagulation Blood Coagulation Hemostasis Platelet Alpha Granule Protein Activation Cascade Regulation Of Body Fluid Levels Cell-substrate Adhesion External Side Of Plasma Membrane Cell-matrix Adhesion Integrin Binding Platelet Alpha Granule Lumen Cell Adhesion Extracellular Space Extracellular Matrix Negative Regulation Of Endothelial Cell Apoptotic Process Blood Microparticle Regulation Of Endothelial Cell Apoptotic Process Extracellular Exosome Cell Surface Platelet Activation Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Integrin-mediated Signaling Pathway Cell-cell Adhesion Integrin Complex Cell Adhesion Mediated By Integrin Regulation Of ERK1 And ERK2 Cascade Regulation Of Vesicle-mediated Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extracellular Matrix Structural Constituent Extracellular Matrix Binding Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Positive Regulation Of Cell-substrate Adhesion Protein Maturation Positive Regulation Of Leukocyte Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Extrinsic Apoptotic Signaling Pathway Induction Of Bacterial Agglutination Negative Regulation Of Blood Coagulation Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinogen Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Antibacterial Humoral Response Homotypic Cell-cell Adhesion Positive Regulation Of MAPK Cascade	Endoplasmic Reticulum Lumen Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Fibrinolysis Protein Activation Cascade Cell-matrix Adhesion Coagulation Blood Coagulation Hemostasis Platelet Alpha Granule Lumen Blood Microparticle Platelet Activation Positive Regulation Of Cell-substrate Adhesion Protein Maturation Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Space Negative Regulation Of Coagulation Extracellular Matrix Structural Constituent Positive Regulation Of Rho Protein Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinogen Complex Extracellular Region Extracellular Matrix Fibrillar Collagen Trimer Regulation Of Body Fluid Levels Blood Coagulation, Fibrin Clot Formation Zymogen Activation Protein Processing Regulation Of Biological Quality Platelet-derived Growth Factor Binding Plasminogen Activation Cell Surface Regulation Of Signal Transduction Regulation Of Signaling Protein Folding In Endoplasmic Reticulum Regulation Of Cell Communication Positive Regulation Of Heterotypic Cell-cell Adhesion External Side Of Plasma Membrane Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Collagen Type I Trimer Extracellular Matrix Organization Regulation Of Wound Healing Extracellular Structure Organization Platelet Alpha Granule
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