FGG and FGA

Number of citations of the paper that reports this interaction (PMID 12356313)
12

Data Source:
HPRD (in vitro)

		FGG	FGA
Gene Name		fibrinogen gamma chain	fibrinogen alpha chain
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Vesicle Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Receptor Binding Structural Molecule Activity Protein Binding, Bridging Metal Ion Binding Cell Adhesion Molecule Binding	Receptor Binding Structural Molecule Activity Protein Binding Protein Binding, Bridging Cell Adhesion Molecule Binding
	Biological Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation, Common Pathway Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation	p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Amyloids Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Alpha-D-Mannose
Diseases
GWAS		D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 23650146)	D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494)
Protein-Protein Interactions		10 interactors: F13A1 F13B FGA FGB ICAM1 ITGAM ITGB3 SERPINA5 VKORC1 VTN	15 interactors: CDH5 F13A1 F2 FGB FGG HRG ITGA2B ITGB3 NID1 PLAT PRRC2A SERPINA5 SERPINF2 THBS1 UBC
Entrez ID		2266	2243
HPRD ID		00621	00619
Ensembl ID		ENSG00000171557	ENSG00000171560
Uniprot IDs		P02679	P02671
PDB IDs		1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS	1BBR 1DM4 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Platelet Degranulation Cell Activation Homotypic Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasoconstriction Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Cell-matrix Adhesion Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Single Organismal Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Vasoconstriction Cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Exocytosis Innate Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Secretion By Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune System Process Secretion Immune Response Leukocyte Migration Regulation Of Phosphorylation Defense Response	Platelet Degranulation Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Exocytosis Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Fibrinolysis Secretion By Cell Extracellular Matrix Organization Extracellular Structure Organization Secretion Fibrinolysis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell-substrate Adhesion Platelet Aggregation Response To Stress Positive Regulation Of Coagulation Regulation Of Wound Healing Negative Regulation Of Protein Metabolic Process Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell-matrix Adhesion Negative Regulation Of Coagulation Regulation Of Proteolysis Positive Regulation Of Cell Adhesion Negative Regulation Of Wound Healing Regulation Of Protein Processing Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Establishment Of Localization In Cell Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cell Adhesion Regulation Of Endothelial Cell Apoptotic Process Cellular Localization Negative Regulation Of Endothelial Cell Chemotaxis Cell Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus
Tagcloud ?		apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate	antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted
Tagcloud (Difference) ?		apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate	antipsychotic antipsychotics app began caution combinations commonly concurrent contrasts dementia exploring hazardous hospitalized hypnotics monotherapy odds polypharmacy prescribed prescribing quetiapine risperidone schizophrenia sedatives sga taiwan tolerability trends warning warranted
Tagcloud (Intersection) ?