SMG7 and SIRPA

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		SMG7	SIRPA
Description		SMG7 nonsense mediated mRNA decay factor	signal regulatory protein alpha
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GO Annotations	Cellular Component	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol	Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding	Protein Phosphatase Inhibitor Activity Protein Binding SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation	Cell Adhesion Regulation Of Gene Expression Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Cell-cell Adhesion Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 26502338 27399966 28714469)	Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 19820697 22139419 27863252 32888494) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		7 interacting genes: FGFR3 GSK3A GSK3B MDM2 RAD17 SIRPA SMG5	60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM
Entrez ID		9887	140885
HPRD ID		10723	03912
Ensembl ID		ENSG00000116698	ENSG00000198053
Uniprot IDs		A0A8I5KSL3 A0A8I5KYV3 E9PD50 Q6TV06 Q92540	P78324
PDB IDs		1YA0	2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV 7KPG 7ST5 7YGG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Beta-catenin Destruction Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Proteasomal Protein Catabolic Process Protein Kinase A Catalytic Subunit Binding Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Tau-protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Heart Valve Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Phosphorus Metabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Biosynthetic Process Regulation Of Protein Export From Nucleus Regulation Of Glycogen Metabolic Process Tau Protein Binding Negative Regulation Of Cell Development Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Lipid Regulation Of Cell Adhesion Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Permeability Regulation Of Developmental Growth	Extracellular Exosome Focal Adhesion Supramolecular Fiber Organization ATP-dependent Protein Folding Chaperone Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Folding Chaperone Structural Constituent Of Skin Epidermis Cytoplasm Keratin Filament Nucleotide Binding Intermediate Filament Unfolded Protein Binding Structural Molecule Activity Cytoskeleton Organization Protein Folding Protein Folding In Endoplasmic Reticulum Non-membrane Spanning Protein Tyrosine Phosphatase Activity Maintenance Of Location Plasma Membrane Bounded Cell Projection Organization Organelle Organization Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Cadherin Binding T Cell Costimulation Protein Metabolic Process Protein Binding Platelet Formation Regulation Of Nitric Oxide Biosynthetic Process RNA Binding Response To Interleukin-12 Megakaryocyte Development Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Metabolic Process Heat Shock Protein Binding Regulation Of Nitric Oxide Metabolic Process Epithelial Cell Differentiation ATP Binding MHC Class II Protein Complex Binding Cell Projection Organization Sequestering Of Calcium Ion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Maintenance Of Location In Cell Protein Modification Process Glutamatergic Synapse Cytoskeleton
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