SMG7 and SMG5

Number of citations of the paper that reports this interaction (PMID 14636577)
79

Data Source:
HPRD (in vivo)

		SMG7	SMG5
Gene Name		SMG7 nonsense mediated mRNA decay factor	SMG5 nonsense mediated mRNA decay factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Cytoskeleton	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase 2A Binding	Protein Binding Protein Phosphatase 2A Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		2 interactors: FGFR3 SMG5	7 interactors: APP SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		9887	23381
HPRD ID		10723	16869
Ensembl ID		ENSG00000116698	ENSG00000198952
Uniprot IDs		Q6TV06 Q92540	Q9UPR3
PDB IDs		1YA0	2HWY
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Alveolar Secondary Septum Development Axonogenesis Involved In Innervation Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Chondrocyte Proliferation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Astrocyte Differentiation Lung Saccule Development Bone Maturation Lens Fiber Cell Development Central Nervous System Myelination Epithelial Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Regulation Of Astrocyte Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Smoothened Signaling Pathway Lens Fiber Cell Differentiation Negative Regulation Of Glial Cell Differentiation Innervation Substantia Nigra Development Oligodendrocyte Development Endochondral Ossification Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphorus Metabolic Process Negative Regulation Of Mitotic Nuclear Division Bone Mineralization Cochlea Development Regulation Of Phosphatidylinositol 3-kinase Activity JAK-STAT Cascade Lung Alveolus Development Neural Nucleus Development Regulation Of Lipid Kinase Activity Inner Ear Receptor Cell Differentiation Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of JAK-STAT Cascade Mechanoreceptor Differentiation MRNA Export From Nucleus Response To Axon Injury Somatic Stem Cell Maintenance Digestive Tract Morphogenesis Lung Epithelium Development RNA Export From Nucleus Positive Regulation Of Neuron Death Positive Regulation Of Phospholipase Activity Regulation Of Glial Cell Differentiation	MRNA Export From Nucleus RNA Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Export MRNA Transport RNA Transport Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport Cellular Macromolecule Catabolic Process Gene Expression DNA Metabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Transport Cytoplasmic Transport Nitrogen Compound Metabolic Process RNA Metabolic Process Catabolic Process Establishment Of Localization In Cell Cellular Localization Telomere Maintenance Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Production Of SiRNA Involved In RNA Interference DNA Repair Negative Regulation Of RNA Interference Transcription, RNA-templated Positive Regulation Of Chaperone-mediated Protein Complex Assembly Synaptic Growth At Neuromuscular Junction Regulation Of Dephosphorylation Regulation Of Protein Binding Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression, Epigenetic Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Ubiquitin-dependent SMAD Protein Catabolic Process Telomere Assembly
Tagcloud ?		codons concept decay disrupt disrupted expected full integrity library minimal mrnas mutated nanomolar nmd nonsense pharmacologic pocket premature proof ptc read restoration restore serve termination transcripts upf1 upregulated virtual
Tagcloud (Difference) ?		codons concept decay disrupt disrupted expected full integrity library minimal mrnas mutated nanomolar nmd nonsense pharmacologic pocket premature proof ptc read restoration restore serve termination transcripts upf1 upregulated virtual
Tagcloud (Intersection) ?