SMG7 and FGFR3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SMG7	FGFR3
Gene Name		SMG7 nonsense mediated mRNA decay factor	fibroblast growth factor receptor 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Cytoskeleton	Extracellular Region Nucleus Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Transport Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase 2A Binding	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Morphogenesis Of An Epithelium Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Epidermal Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Central Nervous System Myelination Bone Mineralization Forebrain Development Positive Regulation Of Protein Ubiquitination Somatic Stem Cell Maintenance Chondrocyte Proliferation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Smoothened Signaling Pathway Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Digestive Tract Morphogenesis Negative Regulation Of Developmental Growth Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Inner Ear Receptor Cell Differentiation Bone Morphogenesis Axonogenesis Involved In Innervation Alveolar Secondary Septum Development Lens Fiber Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Epithelial Cell Fate Commitment Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cochlea Development Positive Regulation Of Canonical Wnt Signaling Pathway Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Signaling by FGFR in disease Signaling by FGFR3 mutants Signaling by activated point mutants of FGFR3 Signaling by FGFR mutants t(4;14) translocations of FGFR3
Drugs
Diseases
GWAS			Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		2 interactors: FGFR3 SMG5	38 interactors: ARAP1 ATF3 BORA C6orf47 CCDC17 CHGB CTSK EPHA4 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KIAA1377 KRT8 NDUFS6 POLA2 PTK2B RADIL RNF130 RPL8 SH2B1 SLC25A6 SMG7 STAT1 STAT3
Entrez ID		9887	2261
HPRD ID		10723	00624
Ensembl ID		ENSG00000116698	ENSG00000068078
Uniprot IDs		Q6TV06 Q92540	P22607 Q0IJ44
PDB IDs		1YA0	1RY7 4K33
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Alveolar Secondary Septum Development Axonogenesis Involved In Innervation Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Chondrocyte Proliferation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Astrocyte Differentiation Lung Saccule Development Bone Maturation Lens Fiber Cell Development Central Nervous System Myelination Epithelial Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Regulation Of Astrocyte Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Smoothened Signaling Pathway Lens Fiber Cell Differentiation Negative Regulation Of Glial Cell Differentiation Innervation Substantia Nigra Development Oligodendrocyte Development Endochondral Ossification Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphorus Metabolic Process Negative Regulation Of Mitotic Nuclear Division Bone Mineralization Cochlea Development Regulation Of Phosphatidylinositol 3-kinase Activity JAK-STAT Cascade Lung Alveolus Development Neural Nucleus Development Regulation Of Lipid Kinase Activity Inner Ear Receptor Cell Differentiation Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of JAK-STAT Cascade Mechanoreceptor Differentiation MRNA Export From Nucleus Response To Axon Injury Somatic Stem Cell Maintenance Digestive Tract Morphogenesis Lung Epithelium Development RNA Export From Nucleus Positive Regulation Of Neuron Death Positive Regulation Of Phospholipase Activity Regulation Of Glial Cell Differentiation	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Insulin Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Division Response To Hormone Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Immune System Process Regulation Of Cell Proliferation Response To Organic Substance Cell-cell Signaling Response To Stress Anatomical Structure Morphogenesis Cell Differentiation Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Anatomical Structure Development Regulation Of Epithelial Cell Migration
Tagcloud ?		codons concept decay disrupt disrupted expected full integrity library minimal mrnas mutated nanomolar nmd nonsense pharmacologic pocket premature proof ptc read restoration restore serve termination transcripts upf1 upregulated virtual	accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying
Tagcloud (Difference) ?		codons concept decay disrupt disrupted expected full integrity library minimal mrnas mutated nanomolar nmd nonsense pharmacologic pocket premature proof ptc read restoration restore serve termination transcripts upf1 upregulated virtual	accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying
Tagcloud (Intersection) ?