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SMG7
Gene Name
SMG7 nonsense mediated mRNA decay factor
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Intermediate Filament Cytoskeleton
Molecular Function
Protein Binding
Protein Phosphatase 2A Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
MRNA Export From Nucleus
Gene Expression
Regulation Of Dephosphorylation
Pathways
Nonsense-Mediated Decay (NMD)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-protein Interactions
2 interactors:
FGFR3
SMG5
Entrez ID
9887
HPRD ID
10723
Ensembl ID
ENSG00000116698
Uniprot IDs
Q6TV06
Q92540
PDB IDs
1YA0
Enriched GO Terms of Interacting Partners
?
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Alveolar Secondary Septum Development
Axonogenesis Involved In Innervation
Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Chondrocyte Proliferation
Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Negative Regulation Of Astrocyte Differentiation
Lung Saccule Development
Bone Maturation
Lens Fiber Cell Development
Central Nervous System Myelination
Epithelial Cell Fate Commitment
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Lens Morphogenesis In Camera-type Eye
Endochondral Bone Growth
Regulation Of Astrocyte Differentiation
Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Negative Regulation Of Smoothened Signaling Pathway
Lens Fiber Cell Differentiation
Negative Regulation Of Glial Cell Differentiation
Innervation
Substantia Nigra Development
Oligodendrocyte Development
Endochondral Ossification
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Mitotic Nuclear Division
Bone Mineralization
Cochlea Development
Regulation Of Phosphatidylinositol 3-kinase Activity
JAK-STAT Cascade
Lung Alveolus Development
Neural Nucleus Development
Regulation Of Lipid Kinase Activity
Inner Ear Receptor Cell Differentiation
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of JAK-STAT Cascade
Mechanoreceptor Differentiation
MRNA Export From Nucleus
Response To Axon Injury
Somatic Stem Cell Maintenance
Digestive Tract Morphogenesis
Lung Epithelium Development
RNA Export From Nucleus
Positive Regulation Of Neuron Death
Positive Regulation Of Phospholipase Activity
Regulation Of Glial Cell Differentiation
Tagcloud
?
codons
concept
decay
disrupt
disrupted
expected
full
integrity
library
minimal
mrnas
mutated
nanomolar
nmd
nonsense
pharmacologic
pocket
premature
proof
ptc
read
restoration
restore
serve
termination
transcripts
upf1
upregulated
virtual