SMG7

Description		SMG7 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 26502338 27399966 28714469)
Novel Interacting Genes		1 novel interacting genes: TNFSF4
Interacting Genes		7 interacting genes: FGFR3 GSK3A GSK3B MDM2 RAD17 SIRPA SMG5
Entrez ID		9887
HPRD ID		10723
Ensembl ID		ENSG00000116698
Uniprot IDs		A0A8I5KSL3 A0A8I5KYV3 E9PD50 Q6TV06 Q92540
PDB IDs		1YA0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Beta-catenin Destruction Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Proteasomal Protein Catabolic Process Protein Kinase A Catalytic Subunit Binding Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Tau-protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Heart Valve Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Phosphorus Metabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Biosynthetic Process Regulation Of Protein Export From Nucleus Regulation Of Glycogen Metabolic Process Tau Protein Binding Negative Regulation Of Cell Development Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Lipid Regulation Of Cell Adhesion Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Membrane Permeability Regulation Of Developmental Growth
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