SMG7

Gene Name		SMG7 nonsense mediated mRNA decay factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Protein Phosphatase 2A Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: FGFR3 SMG5
Entrez ID		9887
HPRD ID		10723
Ensembl ID		ENSG00000116698
Uniprot IDs		Q6TV06 Q92540
PDB IDs		1YA0
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Alveolar Secondary Septum Development Axonogenesis Involved In Innervation Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Chondrocyte Proliferation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Astrocyte Differentiation Lung Saccule Development Bone Maturation Lens Fiber Cell Development Central Nervous System Myelination Epithelial Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Regulation Of Astrocyte Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Smoothened Signaling Pathway Lens Fiber Cell Differentiation Negative Regulation Of Glial Cell Differentiation Innervation Substantia Nigra Development Oligodendrocyte Development Endochondral Ossification Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Phosphorus Metabolic Process Negative Regulation Of Mitotic Nuclear Division Bone Mineralization Cochlea Development Regulation Of Phosphatidylinositol 3-kinase Activity JAK-STAT Cascade Lung Alveolus Development Neural Nucleus Development Regulation Of Lipid Kinase Activity Inner Ear Receptor Cell Differentiation Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of JAK-STAT Cascade Mechanoreceptor Differentiation MRNA Export From Nucleus Response To Axon Injury Somatic Stem Cell Maintenance Digestive Tract Morphogenesis Lung Epithelium Development RNA Export From Nucleus Positive Regulation Of Neuron Death Positive Regulation Of Phospholipase Activity Regulation Of Glial Cell Differentiation
Tagcloud ?		codons concept decay disrupt disrupted expected full integrity library minimal mrnas mutated nanomolar nmd nonsense pharmacologic pocket premature proof ptc read restoration restore serve termination transcripts upf1 upregulated virtual