FGF7 and FGFR2

Number of citations of the paper that reports this interaction (PMID 7687739)
68

Data Source:
HPRD (in vivo)

		FGF7	FGFR2
Gene Name		fibroblast growth factor 7	fibroblast growth factor receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Golgi Apparatus	Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Intracellular Membrane-bounded Organelle Excitatory Synapse
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ureteric Bud Development In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Mesenchymal Cell Proliferation Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Axonogenesis Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Post-embryonic Development Embryonic Pattern Specification Organ Morphogenesis Regulation Of Cell Fate Commitment Positive Regulation Of Phospholipase Activity Morphogenesis Of Embryonic Epithelium Peptidyl-tyrosine Phosphorylation Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Pyramidal Neuron Development Gland Morphogenesis Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Lung Development Epithelial Cell Differentiation Midbrain Development Otic Vesicle Formation Hair Follicle Morphogenesis Lacrimal Gland Development Regulation Of Osteoblast Proliferation Multicellular Organism Growth Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Odontogenesis Positive Regulation Of MAPK Cascade Innate Immune Response Cell Fate Commitment Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lung Alveolus Development Mesodermal Cell Differentiation Synaptic Vesicle Transport Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Embryonic Organ Development Reproductive Structure Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Epidermis Morphogenesis Branching Morphogenesis Of A Nerve Mesenchymal Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cell Division Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Limb Bud Formation Bone Development Bone Morphogenesis Coronal Suture Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Elongation Involved In Lung Branching Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Gland Morphogenesis Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Lateral Sprouting From An Epithelium Mammary Gland Bud Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branch Elongation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Mesenchymal Cell Differentiation Involved In Lung Development Mesenchymal Cell Proliferation Involved In Lung Development Endodermal Digestive Tract Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FGFR2 ligand binding and activation FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by FGFR2 amplification mutants Signaling by FGFR2 mutants Signaling by FGFR in disease Signaling by FGFR mutants Activated point mutants of FGFR2
Drugs			Palifermin Thalidomide SU4984 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Regorafenib Ponatinib
Diseases
GWAS		Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)	Breast cancer ( 21263130 20872241 23354978 17529967 23535729 17529973 22951594 20453838 19330030 21060860) Prostate-specific antigen levels ( 21160077)
Protein-Protein Interactions		13 interactors: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 UBQLN1	21 interactors: APP CACNA1D EPHA4 FGF1 FGF10 FGF17 FGF18 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 ITGA5 NEDD4 PAK4 PLCG1 PPM1A PTK2B
Entrez ID		2252	2263
HPRD ID		01022	01492
Ensembl ID			ENSG00000066468
Uniprot IDs		P21781 Q6FGV5	D2CGD1 P21802
PDB IDs			1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J95 4J96 4J97 4J98 4J99
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Tissue Development Extracellular Matrix Disassembly Cellular Response To Organonitrogen Compound Cellular Response To Organic Substance Skeletal System Morphogenesis Axonogenesis Bone Morphogenesis Ossification Skeletal System Development Endochondral Ossification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Organ Morphogenesis Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Embryo Development Cell Morphogenesis Involved In Differentiation Collagen Catabolic Process Inner Ear Development Response To Organic Substance Regulation Of ERK1 And ERK2 Cascade Cartilage Development Neurotrophin TRK Receptor Signaling Pathway Head Development Neuron Projection Development Collagen Metabolic Process Otic Vesicle Development Neurotrophin Signaling Pathway Response To Organonitrogen Compound Cell Projection Morphogenesis Bone Development Endochondral Bone Morphogenesis Regulation Of Signal Transduction Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Ear Development Cell Part Morphogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Connective Tissue Development Blood Vessel Development Vasculature Development Peptidyl-tyrosine Phosphorylation Inner Ear Morphogenesis Neuron Development Central Nervous System Development	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Response To Hormone Defense Response Immune System Process Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Cell-cell Signaling Signaling Positive Regulation Of Cell Division Cell Communication Regulation Of Immune System Process Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Response To Stress System Development
Tagcloud ?		abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces	altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 fibroblast gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal structurally
Tagcloud (Difference) ?		abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 therapeutically transcript transduces	altogether basic bfgf bfgf1 bfgf55 bfgf75 bk1 bk2 chimera chimeras confer fgfr1 fgfr4 gfg interacted kb1 kb2 keratinocyte kgf kgf111 kgf31 kgf91 kgfr neutralized neutralizing reciprocal
Tagcloud (Intersection) ?		fibroblast structurally