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FGF7 and DESI1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
FGF7
DESI1
Gene Name
fibroblast growth factor 7
desumoylating isopeptidase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Golgi Apparatus
Nucleus
Cytoplasm
Molecular Function
Fibroblast Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemoattractant Activity
Peptidase Activity
Identical Protein Binding
Biological Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermis Development
Response To Wounding
Mesenchymal Cell Proliferation
Positive Regulation Of Keratinocyte Proliferation
Hair Follicle Morphogenesis
Actin Cytoskeleton Reorganization
Protein Localization To Cell Surface
Fc-epsilon Receptor Signaling Pathway
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Cell Division
Branching Involved In Salivary Gland Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Secretion By Lung Epithelial Cell Involved In Lung Growth
Proteolysis
Pathways
Signaling by the B Cell Receptor (BCR)
Phospholipase C-mediated cascade
Signaling by FGFR in disease
SHC-mediated cascade
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Signaling by FGFR2 mutants
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
PI3K/AKT activation
PI-3K cascade
PI3K Cascade
Negative regulation of FGFR signaling
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
Activated point mutants of FGFR2
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by FGFR mutants
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
IRS-mediated signalling
PIP3 activates AKT signaling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
FGFR ligand binding and activation
FGFR2b ligand binding and activation
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Insulin receptor signalling cascade
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
IRS-mediated signalling
FGFR2 ligand binding and activation
FRS2-mediated cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PI3K Cascade
Drugs
Diseases
GWAS
Thyroid hormone levels (
23408906
)
Thyroid volume (
21565293
)
Protein-Protein Interactions
13 interactors:
COL1A1
COL2A1
COL3A1
COL6A1
DESI1
DUSP3
FGFR1
FGFR2
FGFR3
FGFR4
HSPG2
NRP1
UBQLN1
2 interactors:
FGF7
ZBTB46
Entrez ID
2252
27351
HPRD ID
01022
18590
Ensembl ID
ENSG00000100418
Uniprot IDs
P21781
Q6FGV5
Q6ICB0
PDB IDs
3EBQ
Enriched GO Terms of Interacting Partners
?
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Tissue Development
Extracellular Matrix Disassembly
Cellular Response To Organonitrogen Compound
Cellular Response To Organic Substance
Skeletal System Morphogenesis
Axonogenesis
Bone Morphogenesis
Ossification
Skeletal System Development
Endochondral Ossification
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Organ Morphogenesis
Neuron Projection Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Embryo Development
Cell Morphogenesis Involved In Differentiation
Collagen Catabolic Process
Inner Ear Development
Response To Organic Substance
Regulation Of ERK1 And ERK2 Cascade
Cartilage Development
Neurotrophin TRK Receptor Signaling Pathway
Head Development
Neuron Projection Development
Collagen Metabolic Process
Otic Vesicle Development
Neurotrophin Signaling Pathway
Response To Organonitrogen Compound
Cell Projection Morphogenesis
Bone Development
Endochondral Bone Morphogenesis
Regulation Of Signal Transduction
Multicellular Organismal Macromolecule Metabolic Process
Chondrocyte Differentiation
Ear Development
Cell Part Morphogenesis
Cardiovascular System Development
Enzyme Linked Receptor Protein Signaling Pathway
Multicellular Organismal Metabolic Process
Connective Tissue Development
Blood Vessel Development
Vasculature Development
Peptidyl-tyrosine Phosphorylation
Inner Ear Morphogenesis
Neuron Development
Central Nervous System Development
Positive Regulation Of Dendritic Cell Differentiation
Secretion By Lung Epithelial Cell Involved In Lung Growth
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Negative Regulation Of Monocyte Differentiation
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Negative Regulation Of Dendritic Cell Differentiation
Positive Regulation Of Keratinocyte Proliferation
Lung Growth
Negative Regulation Of Granulocyte Differentiation
Regulation Of Dendritic Cell Differentiation
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Negative Regulation Of Macrophage Differentiation
Regulation Of Monocyte Differentiation
Mesenchymal-epithelial Cell Signaling
Regulation Of Branching Involved In Salivary Gland Morphogenesis
Mesenchymal Cell Proliferation
Protein Localization To Cell Surface
Regulation Of Keratinocyte Proliferation
Positive Chemotaxis
Branching Involved In Salivary Gland Morphogenesis
Hair Follicle Morphogenesis
Regulation Of Immune System Process
Epidermis Morphogenesis
Salivary Gland Morphogenesis
Salivary Gland Development
Negative Regulation Of Myeloid Leukocyte Differentiation
Skin Morphogenesis
Exocrine System Development
Regulation Of Morphogenesis Of A Branching Structure
Actin Cytoskeleton Reorganization
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Myeloid Cell Differentiation
Stem Cell Proliferation
Hair Follicle Development
Hair Cycle Process
Organ Growth
Hair Cycle
Regulation Of Myeloid Leukocyte Differentiation
Positive Regulation Of Cell Division
Phosphatidylinositol-mediated Signaling
Regulation Of Epithelial Cell Migration
Insulin Receptor Signaling Pathway
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Gland Morphogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Myeloid Cell Differentiation
Tagcloud
?
abrogated
abundance
ck1
correlates
csnk1e
disrupting
erk
fgf1
fgfr
fibroblast
grb2
message
modulated
motifs
negatively
neurite
outgrowth
pc12
ras
sevenless
son
sos
sprouty2
spry2
structurally
therapeutically
transcript
transduces
Tagcloud (Difference)
?
abrogated
abundance
ck1
correlates
csnk1e
disrupting
erk
fgf1
fgfr
fibroblast
grb2
message
modulated
motifs
negatively
neurite
outgrowth
pc12
ras
sevenless
son
sos
sprouty2
spry2
structurally
therapeutically
transcript
transduces
Tagcloud (Intersection)
?