FGF7 and DESI1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FGF7	DESI1
Description		fibroblast growth factor 7	desumoylating isopeptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Postsynapse GABA-ergic Synapse	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	Protein Binding Peptidase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity DeSUMOylase Activity Identical Protein Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Importin-alpha Family Protein Binding
	Biological Process	Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Signal Transduction Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Neurogenesis Actin Cytoskeleton Organization Lung Development Regulation Of Cell Migration Hair Follicle Morphogenesis Protein Localization To Cell Surface Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of Synapse Maturation Positive Regulation Of Myoblast Proliferation	Proteolysis Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Depalmitoylation
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Lung adenocarcinoma ( 28604730) Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)	General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 PTX3 UBQLN1	32 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RNF4 RPS27A SHISA4 SHISA5 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLNL UHRF2 XPO1 ZBTB46
Entrez ID		2252	27351
HPRD ID		01022	18590
Ensembl ID		ENSG00000140285	ENSG00000100418
Uniprot IDs		P21781	Q6ICB0
PDB IDs			3EBQ
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Activity Platelet-derived Growth Factor Binding Positive Regulation Of Phospholipase Activity Extracellular Region Animal Organ Morphogenesis Fibroblast Growth Factor Binding Biomineral Tissue Development Cartilage Development Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Animal Organ Development Positive Regulation Of Lipase Activity System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fibrillar Collagen Trimer Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Growth Factor Chondrocyte Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Collagen Fibril Organization Collagen Trimer Developmental Growth Receptor Complex Anatomical Structure Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Cell Surface Receptor Signaling Pathway Extracellular Matrix Tissue Development Extracellular Matrix Organization Extracellular Structure Organization Lung Development Endochondral Ossification Cellular Response To Fibroblast Growth Factor Stimulus Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of ERK1 And ERK2 Cascade Regulation Of Signal Transduction Identical Protein Binding Bone Morphogenesis Cell Differentiation Ossification Protein Tyrosine Kinase Activity Positive Regulation Of Cell Population Proliferation Regulation Of Developmental Growth Response To Fibroblast Growth Factor Sensory Perception Of Mechanical Stimulus Response To Oxygen Levels	Protein Tag Activity TRNA Threonylcarbamoyladenosine Metabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Ubiquitin Protein Ligase Binding Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Granulocyte Differentiation Protein Modification By Small Protein Conjugation Vesicle
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