FGF7 and HSPG2

Number of citations of the paper that reports this interaction (PubMedID 10702276)
0

Data Source:
BioGRID (pull down, affinity chromatography technology, two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		FGF7	HSPG2
Description		fibroblast growth factor 7	heparan sulfate proteoglycan 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Postsynapse GABA-ergic Synapse	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding
	Biological Process	Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Signal Transduction Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Neurogenesis Actin Cytoskeleton Organization Lung Development Regulation Of Cell Migration Hair Follicle Morphogenesis Protein Localization To Cell Surface Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of Synapse Maturation Positive Regulation Of Myoblast Proliferation	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Palifermin
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Blood protein levels ( 30072576) Lung adenocarcinoma ( 28604730) Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)	Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		14 interacting genes: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 PTX3 UBQLN1	33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1
Entrez ID		2252	3339
HPRD ID		01022	00804
Ensembl ID		ENSG00000140285	ENSG00000142798
Uniprot IDs		P21781	P98160
PDB IDs			3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Activity Platelet-derived Growth Factor Binding Positive Regulation Of Phospholipase Activity Extracellular Region Animal Organ Morphogenesis Fibroblast Growth Factor Binding Biomineral Tissue Development Cartilage Development Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Animal Organ Development Positive Regulation Of Lipase Activity System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fibrillar Collagen Trimer Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Growth Factor Chondrocyte Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Collagen Fibril Organization Collagen Trimer Developmental Growth Receptor Complex Anatomical Structure Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Cell Surface Receptor Signaling Pathway Extracellular Matrix Tissue Development Extracellular Matrix Organization Extracellular Structure Organization Lung Development Endochondral Ossification Cellular Response To Fibroblast Growth Factor Stimulus Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of ERK1 And ERK2 Cascade Regulation Of Signal Transduction Identical Protein Binding Bone Morphogenesis Cell Differentiation Ossification Protein Tyrosine Kinase Activity Positive Regulation Of Cell Population Proliferation Regulation Of Developmental Growth Response To Fibroblast Growth Factor Sensory Perception Of Mechanical Stimulus Response To Oxygen Levels	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development
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