FGF7 and DUSP3

Number of citations: 38 (PubMedID 1281549)
Data Source: HPRD (in vitro)

		FGF7	DUSP3
Name		fibroblast growth factor 7	dual specificity phosphatase 3
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Postsynapse GABA-ergic Synapse	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity Protein Kinase Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Signal Transduction Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Neurogenesis Actin Cytoskeleton Organization Lung Development Regulation Of Cell Migration Hair Follicle Morphogenesis Protein Localization To Cell Surface Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of Synapse Maturation Positive Regulation Of Myoblast Proliferation	Negative Regulation Of Signal Transduction Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells	ERKs are inactivated
GWAS		Blood protein levels ( 30072576 ) Lung adenocarcinoma ( 28604730 ) Thyroid hormone levels ( 23408906 ) Thyroid volume ( 21565293 )	Fractures ( 30158200 ) HDL cholesterol ( 25961943 27036123 ) High density lipoprotein cholesterol levels ( 33339817 ) Metabolite levels ( 23823483 ) Triglycerides ( 25961943 )
Novel Interactors		1 novel interactors: PTEN	None recorded
Interacting Genes		14 interacting genes: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 PTX3 UBQLN1	15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70
Entrez ID		2252	1845
HPRD ID		01022	02553
Ensembl ID		ENSG00000140285	ENSG00000108861
Uniprot IDs		P21781	P51452
PDB IDs		Not available	1J4X 1VHR 3F81 8TK2 8TK3 8TK4 8TK5 8TK6 9DJ9
GO Terms Enriched among Interactors		Fibroblast Growth Factor Receptor Activity Platelet-derived Growth Factor Binding Positive Regulation Of Phospholipase Activity Extracellular Region Animal Organ Morphogenesis Fibroblast Growth Factor Binding Biomineral Tissue Development Cartilage Development Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Animal Organ Development Positive Regulation Of Lipase Activity System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fibrillar Collagen Trimer Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Growth Factor Chondrocyte Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Collagen Fibril Organization Collagen Trimer Developmental Growth Receptor Complex Anatomical Structure Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Cell Surface Receptor Signaling Pathway Extracellular Matrix Tissue Development Extracellular Matrix Organization Extracellular Structure Organization Lung Development Endochondral Ossification Cellular Response To Fibroblast Growth Factor Stimulus Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of ERK1 And ERK2 Cascade Regulation Of Signal Transduction Identical Protein Binding Bone Morphogenesis Cell Differentiation Ossification Protein Tyrosine Kinase Activity Positive Regulation Of Cell Population Proliferation Regulation Of Developmental Growth Response To Fibroblast Growth Factor Sensory Perception Of Mechanical Stimulus Response To Oxygen Levels	Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Golgi Inheritance Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Trachea Formation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Protein Kinase Activity Positive Regulation Of Protein Metabolic Process ERK1 And ERK2 Cascade Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Epithelial Cell Proliferation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Golgi Organization