MDGA1

Description		MAM domain containing glycosylphosphatidylinositol anchor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Axon Dendrite Side Of Membrane GABA-ergic Synapse
	Molecular Function
	Biological Process	Neuron Migration Nervous System Development Brain Development Spinal Cord Association Neuron Differentiation Cerebral Cortex Radially Oriented Cell Migration Cell Differentiation Dopamine Metabolic Process Serotonin Metabolic Process Prepulse Inhibition Presynapse Assembly Regulation Of Synaptic Membrane Adhesion Inhibitory Synapse Assembly Regulation Of Presynapse Assembly
Pathways		Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Daytime nap ( 33568662) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Lamb consumption ( 32066663) Neurological blood protein biomarker levels ( 31320639) Restless legs syndrome ( 29029846)
Interacting Genes		2 interacting genes: LNX2 NLGN2
Entrez ID		266727
HPRD ID		14374
Ensembl ID		ENSG00000112139
Uniprot IDs		A0A7P0TB62 Q8NFP4
PDB IDs		5V5V 5V5W 5XEQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T-SNARE Clustering Jump Response Glycinergic Synapse Ribbon Synapse Postsynaptic Membrane Assembly Terminal Button Organization Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Inhibitory Postsynaptic Potential Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Protein Localization To Synapse Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Synaptic Vesicle Clustering Thigmotaxis Neuron To Neuron Synapse Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neurexin Family Protein Binding Regulation Of Respiratory Gaseous Exchange By Nervous System Process Dopaminergic Synapse Locomotory Exploration Behavior Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Inhibitory Synapse Neurotransmitter-gated Ion Channel Clustering Presynapse Assembly Presynaptic Membrane Organization Postsynaptic Specialization Assembly Positive Regulation Of Synaptic Transmission, GABAergic Insulin Metabolic Process Presynapse Organization Cell-cell Junction Maintenance Regulation Of Respiratory Gaseous Exchange Inhibitory Synapse Assembly Postsynaptic Specialization Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Regulation Of Protein Localization To Synapse Excitatory Synapse Protein Localization To Cell Surface Postsynaptic Specialization Membrane Positive Regulation Of Excitatory Postsynaptic Potential Synaptic Transmission, GABAergic Exploration Behavior Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Dendritic Spine Development Dendritic Shaft Sensory Perception Of Pain
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