MTURN and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTURN	TP53BP2
Description		maturin, neural progenitor differentiation regulator homolog	tumor protein p53 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding
	Biological Process	Regulation Of Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of ERK1 And ERK2 Cascade	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis
Pathways			Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Cadmium levels ( 26025379)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)
Interacting Genes		23 interacting genes: AP2M1 APP ARRDC1 DAZAP2 MKRN1 PLEKHB2 REL RNF41 RPS27A SH3RF1 SSX1 SUSD6 TMEM239 TNFRSF19 TP53BP2 TRAF6 TRIM38 TRIM39 TRIM5 TRIM8 UBA52 UBB UBC	119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		222166	7159
HPRD ID		07635	11803
Ensembl ID		ENSG00000180354	ENSG00000143514
Uniprot IDs		Q8N3F0	Q13625
PDB IDs			1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Tag Activity Ubiquitin Protein Ligase Activity Protein Modification Process Endocytic Vesicle Membrane Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Innate Immune Response Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Endosome Membrane Defense Response To Symbiont Regulation Of JNK Cascade Positive Regulation Of Cell Communication Defense Response To Other Organism Positive Regulation Of Signaling Canonical NF-kappaB Signal Transduction Modification-dependent Protein Catabolic Process Vesicle Protein Autoubiquitination Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Mitochondrial Outer Membrane Regulation Of Signal Transduction Regulation Of MAPK Cascade Cytosol Suppression Of Viral Release By Host Identical Protein Binding Positive Regulation Of MAPK Cascade Macromolecule Catabolic Process Regulation Of Viral Entry Into Host Cell Protein Serine/threonine Kinase Binding Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Zinc Ion Binding Transcription Coactivator Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Receptor Internalization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Lipopolysaccharide-mediated Signaling Pathway Proteolysis	Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression
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