MTURN and MKRN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTURN	MKRN1
Description		maturin, neural progenitor differentiation regulator homolog	makorin ring finger protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytosol
	Molecular Function	Protein Binding	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of ERK1 And ERK2 Cascade	Protein Polyubiquitination Protein Ubiquitination
Pathways			AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cadmium levels ( 26025379)	Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) Immature fraction of reticulocytes ( 32888494) Number of sexual partners ( 30643258)
Interacting Genes		23 interacting genes: AP2M1 APP ARRDC1 DAZAP2 MKRN1 PLEKHB2 REL RNF41 RPS27A SH3RF1 SSX1 SUSD6 TMEM239 TNFRSF19 TP53BP2 TRAF6 TRIM38 TRIM39 TRIM5 TRIM8 UBA52 UBB UBC	28 interacting genes: APC ASH2L BYSL CDKN2A CSNK1G1 DAXX DUSP23 EXOSC8 FADD FAM161A KCNH1 MAP1LC3B MTURN NAA10 OTUB2 PABPC1 RAD23A RAD23B RPS10 SDCBP SLC13A1 TSC2 UBASH3A UBE2D1 UBE2D3 UBE2D4 UBE2W YOD1
Entrez ID		222166	23608
HPRD ID		07635	09673
Ensembl ID		ENSG00000180354	ENSG00000133606
Uniprot IDs		Q8N3F0	Q9UHC7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Tag Activity Ubiquitin Protein Ligase Activity Protein Modification Process Endocytic Vesicle Membrane Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Innate Immune Response Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Endosome Membrane Defense Response To Symbiont Regulation Of JNK Cascade Positive Regulation Of Cell Communication Defense Response To Other Organism Positive Regulation Of Signaling Canonical NF-kappaB Signal Transduction Modification-dependent Protein Catabolic Process Vesicle Protein Autoubiquitination Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Mitochondrial Outer Membrane Regulation Of Signal Transduction Regulation Of MAPK Cascade Cytosol Suppression Of Viral Release By Host Identical Protein Binding Positive Regulation Of MAPK Cascade Macromolecule Catabolic Process Regulation Of Viral Entry Into Host Cell Protein Serine/threonine Kinase Binding Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Zinc Ion Binding Transcription Coactivator Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Receptor Internalization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Lipopolysaccharide-mediated Signaling Pathway Proteolysis	Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cytosol Nucleus Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Catabolic Process Cytoplasm Proteolysis Protein Polyubiquitination Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Ubiquitin Protein Ligase Binding Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein K11-linked Deubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Post-translational Protein Modification TOR Signaling Proteasome Binding Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Ubiquitin Binding Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Protein K6-linked Ubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Topologically Incorrect Protein Positive Regulation Of Viral Genome Replication Macromolecule Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Damage Response Ligase Inhibitor Activity Cyclic Nucleotide Binding Interleukin-5 Receptor Complex Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Polyubiquitin Modification-dependent Protein Binding
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