FCGR3A and ZAP70

Number of citations of the paper that reports this interaction (PMID 7819147)
2

Data Source:
HPRD (in vitro)

		FCGR3A	ZAP70
Gene Name		Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	zeta-chain (TCR) associated protein kinase 70kDa
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	IgG Binding	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System	TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System
Drugs			Staurosporine
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PTPRC SHC1 SYK ZAP70 ZBTB25	58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1
Entrez ID		2214	7535
HPRD ID		00903	01495
Ensembl ID		ENSG00000203747	ENSG00000115085
Uniprot IDs		E9PG94 M9MML0 P08637	P43403
PDB IDs		3AY4 3SGJ 3SGK	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Activation Immune Response Positive Regulation Of Immune System Process Response To Stress Cell Activation Regulation Of Cell Activation Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion B Cell Receptor Signaling Pathway Locomotion T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation T Cell Differentiation Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Alpha-beta T Cell Proliferation Blood Coagulation Hemostasis Positive Regulation Of T Cell Differentiation Signal Transduction Lymphocyte Differentiation Leukocyte Activation Positive Regulation Of Lymphocyte Differentiation Cell Migration Regulation Of Cellular Ketone Metabolic Process Beta Selection Phagocytosis	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation
Tagcloud ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Difference) ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Intersection) ?