FCGR3A and S100A4

Number of citations of the paper that reports this interaction (PubMedID 23024279)
45

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)

		FCGR3A	S100A4
Description		Fc gamma receptor IIIa	S100 calcium binding protein A4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Fc-gamma Receptor III Complex Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding IgG Receptor Activity Low-affinity IgG Receptor Activity IgG Binding Immune Receptor Activity	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Chemoattractant Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Antibody-dependent Cellular Cytotoxicity T Cell Mediated Cytotoxicity Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Protein Import Calcium-mediated Signaling Natural Killer Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Proliferation Fc-gamma Receptor Signaling Pathway Macrophage Activation Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway	Epithelial To Mesenchymal Transition Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Chemotaxis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab Amivantamab	Trifluoperazine Copper
Diseases		NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Alanine aminotransferase levels ( 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 23830517 30498034) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908)	Pulse pressure ( 30578418)
Interacting Genes		20 interacting genes: APCS APP CD247 CD38 CD4 CFTR FCER1G FCGR1A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25	29 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 IFNB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100B S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119
Entrez ID		2214	6275
HPRD ID		00903	15914
Ensembl ID		ENSG00000203747	ENSG00000196154
Uniprot IDs		H0Y755 P08637	P26447
PDB IDs		3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5 7SEG 7URU	1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU 6T58 7PSP 7PSQ
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Activation Adaptive Immune Response Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Complex Gamma-delta T Cell Activation Leukocyte Activation Activation Of Immune Response T Cell Differentiation Immune System Process Positive Regulation Of Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation T Cell Selection Defense Response To Bacterium T Cell Activation Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium-mediated Signaling Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Leukocyte Differentiation Defense Response Regulation Of Phagocytosis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Vesicle-mediated Transport Response To Stress Immunoglobulin Mediated Immune Response Membrane Raft Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cytokine Production Plasma Membrane	Cytoplasm Identical Protein Binding Cleavage Furrow Actin Filament Binding Myosin II Complex Myosin Filament Spindle Sperm Annulus Stress Fiber Microfilament Motor Activity Cytoskeleton-dependent Cytokinesis Supramolecular Fiber Cytosol S100 Protein Binding Cell Division Site Septin Ring Septin Complex Cytoskeletal Motor Activity Myosin Complex Regulation Of Developmental Process Actin Filament-based Movement Regulation Of Cell Shape Cellular Response To Actinomycin D Myosin II Filament Calcium-dependent Protein Binding Cadherin Binding Cytoskeleton Supramolecular Fiber Organization Midbody Response To Actinomycin D Muscle Thin Filament Tropomyosin Muscle Contraction Regulation Of Protein Kinase C Signaling Cellular Response To UV-C Actin Binding ADP Binding Actin-mediated Cell Contraction Negative Regulation Of Protein Catabolic Process Regulation Of Cell Morphogenesis Regulation Of Plasma Membrane Repair Muscle System Process Nucleotide Binding Cell Adhesion Cellular Developmental Process System Process Actin Cytoskeleton Regulation Of Protein Localization Sarcomere Positive Regulation Of Gene Expression Regulation Of Protein Processing
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