FCGR3A and FCER1G

Number of citations of the paper that reports this interaction (PMID 15778339)
27

Data Source:
HPRD (in vivo)

		FCGR3A	FCER1G
Gene Name		Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex
	Molecular Function	IgG Binding	Protein Binding IgE Receptor Activity IgE Binding IgG Binding
	Biological Process	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Leukocyte Migration Protein Localization To Plasma Membrane
Pathways		Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System	Platelet Adhesion to exposed collagen FCERI mediated NF-kB activation GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall Innate Immune System
Drugs			Benzylpenicilloyl Polylysine
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PTPRC SHC1 SYK ZAP70 ZBTB25	8 interactors: FCER1A FCGR3A GP6 KIR2DL4 LYN NCR1 PLCG2 SYK
Entrez ID		2214	2207
HPRD ID		00903	00916
Ensembl ID		ENSG00000203747	ENSG00000158869
Uniprot IDs		E9PG94 M9MML0 P08637	P30273
PDB IDs		3AY4 3SGJ 3SGK
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Activation Immune Response Positive Regulation Of Immune System Process Response To Stress Cell Activation Regulation Of Cell Activation Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion B Cell Receptor Signaling Pathway Locomotion T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation T Cell Differentiation Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Alpha-beta T Cell Proliferation Blood Coagulation Hemostasis Positive Regulation Of T Cell Differentiation Signal Transduction Lymphocyte Differentiation Leukocyte Activation Positive Regulation Of Lymphocyte Differentiation Cell Migration Regulation Of Cellular Ketone Metabolic Process Beta Selection Phagocytosis	Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Positive Regulation Of Interleukin-3 Biosynthetic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Mast Cell Activation B Cell Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Response To Stress Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Platelet Activation Immune System Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune Response Serotonin Secretion Phagocytosis Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Ammonium Transport Serotonin Transport Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Immune System Process Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Signaling Leukocyte Activation Regulation Of Platelet Aggregation Cell Communication Regulation Of Exocytosis Leukocyte Activation Involved In Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Body Fluid Levels Immune Response Leukotriene Biosynthetic Process Wound Healing Monoamine Transport
Tagcloud ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?