FARSA and ECSIT

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid, pull down)

		FARSA	ECSIT
Description		phenylalanyl-tRNA synthetase subunit alpha	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	TRNA Binding Nucleotide Binding Magnesium Ion Binding RNA Binding Aminoacyl-tRNA Ligase Activity Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding	Protein Binding Molecular Adaptor Activity
	Biological Process	Translation Phenylalanyl-tRNA Aminoacylation TRNA Aminoacylation Protein Heterotetramerization	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Cytosolic tRNA aminoacylation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs		Phenylalanine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		13 interacting genes: A2M ABI3 APOE COG4 CRIPTO ECSIT ESR1 GORAB HNRNPR OGT PDCD10 PTEN RNF32	53 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		2193	51295
HPRD ID		04227	12225
Ensembl ID		ENSG00000179115	ENSG00000130159
Uniprot IDs		Q6IBR2 Q9Y285	Q9BQ95
PDB IDs		3L4G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Migration Regulation Of Cell Migration Lipid Binding Regulation Of Locomotion Negative Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Oxidoreductase Activity Negative Regulation Of Locomotion Enzyme Binding Regulation Of Innate Immune Response Positive Regulation Of Proteolysis Negative Regulation Of Phospholipid Efflux Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Anatomical Structure Morphogenesis Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Metal Chelating Activity Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Cell Projection Organization Intermediate-density Lipoprotein Particle Clearance Regulation Of Catalytic Activity Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cellular Senescence Regulation Of Phosphorus Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of MAP Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Endothelial Cell Proliferation Cellular Component Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Rhythmic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Junction Assembly Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Negative Regulation Of Complement Activation, Lectin Pathway	Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse
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