FARSA and TDGF1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FARSA	TDGF1
Gene Name		phenylalanyl-tRNA synthetase, alpha subunit	teratocarcinoma-derived growth factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	TRNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation Gene Expression	Activation Of MAPK Activity Vasculogenesis In Utero Embryonic Development Morphogenesis Of A Branching Structure Positive Regulation Of Cell-matrix Adhesion Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Gastrulation Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Somatic Stem Cell Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Transcriptional regulation of pluripotent stem cells Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by NODAL
Drugs		L-Phenylalanine
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		8 interactors: A2M ABI3 APOE ECSIT GORAB HNRNPR RNF32 TDGF1	10 interactors: ACVR1B ACVR1C ANG AP2S1 BAG6 COPS6 FARSA FBLN1 GDF9 LRIF1
Entrez ID		2193	6997
HPRD ID		04227	01757
Ensembl ID		ENSG00000179115	ENSG00000241186
Uniprot IDs		B4E363 Q6IBR2 Q9Y285	F5H1T8 P13385
PDB IDs		3L4G
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Regulation Of Oxidoreductase Activity Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Regulation Of Epithelial Cell Migration Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Gastrulation Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization Regulation Of Catalytic Activity Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Beta-amyloid Clearance Positive Regulation Of Inclusion Body Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Esterification Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering High-density Lipoprotein Particle Assembly Regulation Of Inflammatory Response Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Phospholipid Transport Chylomicron Remnant Clearance Regulation Of MAP Kinase Activity Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Stem Cell Differentiation CGMP-mediated Signaling	Nodal Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Reproductive Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Oocyte Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Oogenesis Negative Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Trophoblast Cell Migration Oocyte Growth Female Gamete Generation Single Organism Reproductive Process Development Of Primary Female Sexual Characteristics Regulation Of Chorionic Trophoblast Cell Proliferation Negative Regulation Of Trophoblast Cell Migration Viral Process Positive Regulation Of Peptidase Activity Diacylglycerol Biosynthetic Process Phenylalanyl-tRNA Aminoacylation Activation Of Phospholipase A2 Activity Regulation Of Progesterone Secretion Negative Regulation Of Cell Growth Regulation Of Secretion Positive Regulation Of Phospholipase A2 Activity Gamete Generation Developmental Process Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Protein Insertion Into ER Membrane Cullin Deneddylation Sexual Reproduction Multicellular Organismal Reproductive Process Development Of Primary Sexual Characteristics Multicellular Organism Reproduction Negative Regulation Of Growth Positive Regulation Of Phosphorylation Protein Deneddylation Germ Cell Development
Tagcloud ?			altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
Tagcloud (Difference) ?			altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
Tagcloud (Intersection) ?