FARSA and PDCD10

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		FARSA	PDCD10
Name		phenylalanyl-tRNA synthetase subunit alpha	programmed cell death 10
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Extracellular Exosome FAR/SIN/STRIPAK Complex
	Molecular Function	TRNA Binding Nucleotide Binding Magnesium Ion Binding RNA Binding Aminoacyl-tRNA Ligase Activity Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding	Protein Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Translation Phenylalanyl-tRNA Aminoacylation TRNA Aminoacylation Protein Heterotetramerization	Angiogenesis Endothelium Development Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAP Kinase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Notch Signaling Pathway Regulation Of Angiogenesis Protein Stabilization Establishment Of Golgi Localization Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Golgi Reassembly Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways		Cytosolic tRNA aminoacylation	None
Drugs		Phenylalanine	None
Diseases		None	Cerebral cavernous malformation
GWAS		Clozapine-induced agranulocytosis ( 25187353 ) Estimated glomerular filtration rate ( 31152163 ) Red blood cell count ( 27863252 ) Red blood cell traits ( 23222517 ) Type 2 diabetes ( 30297969 )	Fast beta electroencephalogram ( 28070124 ) Platelet count ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: RHOA
Interacting Genes		13 interacting genes: A2M ABI3 APOE COG4 CRIPTO ECSIT ESR1 GORAB HNRNPR OGT PDCD10 PTEN RNF32	9 interacting genes: CHMP5 FAM118B FARSA FRYL MINAR1 PLEKHS1 STK24 STK25 STRN
Entrez ID		2193	11235
HPRD ID		04227	10141
Ensembl ID		ENSG00000179115	ENSG00000114209
Uniprot IDs		Q6IBR2 Q9Y285	Q9BUL8
PDB IDs		3L4G	3AJM 3L8I 3L8J 3RQE 3RQF 3RQG 3W8H 3W8I 4GEH 4TVQ
GO Terms Enriched among Interactors		Negative Regulation Of Cell Migration Regulation Of Cell Migration Lipid Binding Regulation Of Locomotion Negative Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Oxidoreductase Activity Negative Regulation Of Locomotion Enzyme Binding Regulation Of Innate Immune Response Positive Regulation Of Proteolysis Negative Regulation Of Phospholipid Efflux Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Anatomical Structure Morphogenesis Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Metal Chelating Activity Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Cell Projection Organization Intermediate-density Lipoprotein Particle Clearance Regulation Of Catalytic Activity Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cellular Senescence Regulation Of Phosphorus Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of MAP Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Endothelial Cell Proliferation Cellular Component Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Rhythmic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Junction Assembly Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Negative Regulation Of Complement Activation, Lectin Pathway	FAR/SIN/STRIPAK Complex Regulation Of Neuron Projection Development Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Mitotic Cytokinetic Process Cytokinetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation