FARSA

Description		phenylalanyl-tRNA synthetase subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Cytosol Phenylalanine-tRNA Ligase Complex Membrane
	Molecular Function	TRNA Binding Nucleotide Binding Magnesium Ion Binding RNA Binding Aminoacyl-tRNA Ligase Activity Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding
	Biological Process	Translation Phenylalanyl-tRNA Aminoacylation TRNA Aminoacylation Protein Heterotetramerization
Pathways		Cytosolic tRNA aminoacylation
Drugs		Phenylalanine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Type 2 diabetes ( 30297969)
Interacting Genes		13 interacting genes: A2M ABI3 APOE COG4 CRIPTO ECSIT ESR1 GORAB HNRNPR OGT PDCD10 PTEN RNF32
Entrez ID		2193
HPRD ID		04227
Ensembl ID		ENSG00000179115
Uniprot IDs		Q6IBR2 Q9Y285
PDB IDs		3L4G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Migration Regulation Of Cell Migration Lipid Binding Regulation Of Locomotion Negative Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Oxidoreductase Activity Negative Regulation Of Locomotion Enzyme Binding Regulation Of Innate Immune Response Positive Regulation Of Proteolysis Negative Regulation Of Phospholipid Efflux Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Anatomical Structure Morphogenesis Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Metal Chelating Activity Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Cell Projection Organization Intermediate-density Lipoprotein Particle Clearance Regulation Of Catalytic Activity Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cellular Senescence Regulation Of Phosphorus Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of MAP Kinase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Endothelial Cell Proliferation Cellular Component Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Rhythmic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Junction Assembly Regulation Of Nitric Oxide Biosynthetic Process Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Negative Regulation Of Complement Activation, Lectin Pathway
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