PTK2B and DLG3

Number of citations of the paper that reports this interaction (PMID 12576483)
15

Data Source:
HPRD (in vivo, in vitro)

		PTK2B	DLG3
Gene Name		protein tyrosine kinase 2 beta	discs, large homolog 3 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Lamellipodium Axon Dendrite Growth Cone Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Apical Dendrite	Extracellular Space Cytoplasm Plasma Membrane Tight Junction Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Growth Cone Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Postsynaptic Membrane
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Binding Protein Binding ATP Binding Protein Complex Binding 3-phosphoinositide-dependent Protein Kinase Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	MAPK Cascade Angiogenesis Oocyte Maturation Response To Hypoxia Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Marginal Zone B Cell Differentiation Protein Complex Assembly Protein Phosphorylation Apoptotic Process Response To Stress Cellular Defense Response Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Mechanical Stimulus Response To Hormone Response To Glucose Response To Lithium Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of CGMP-mediated Signaling Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Glial Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Regulation Of CGMP Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Neuron Projection Development Activation Of Rac GTPase Activity Regulation Of Inositol Trisphosphate Biosynthetic Process Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Response To Immobilization Stress Peptidyl-tyrosine Autophosphorylation Response To Cocaine Response To Drug Response To Hydrogen Peroxide Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Stress Fiber Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Response To Ethanol Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Calcium-mediated Signaling Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To CAMP Response To Calcium Ion Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Cell Polarity Regulation Of Actin Cytoskeleton Reorganization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of B Cell Chemotaxis	Establishment Of Planar Polarity Synaptic Transmission Nervous System Development Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		Signaling by Interleukins Signaling by VEGF Cytokine Signaling in Immune system Interleukin-2 signaling Signal regulatory protein (SIRP) family interactions VEGFA-VEGFR2 Pathway	Axon guidance L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Diseases
GWAS		Dental caries ( 23259602)
Protein-Protein Interactions		70 interactors: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DCC DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70	40 interactors: ABCA1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LPHN1 LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1
Entrez ID		2185	1741
HPRD ID		03131	02177
Ensembl ID		ENSG00000120899	ENSG00000082458
Uniprot IDs		Q14289	Q59FY1 Q92796
PDB IDs		2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3C 3U3F 4EKU 4H1J 4H1M	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signaling Movement Of Cell Or Subcellular Component Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Response To Wounding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Locomotion Wound Healing Immune Response-regulating Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Platelet Activation Regulation Of Immune Response Cell Migration Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Neurotrophin Signaling Pathway Response To Fibroblast Growth Factor Cell Motility Protein Autophosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Cellular Response To Peptide Hormone Stimulus Hemostasis Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Peptide Immune Response Regulation Of Immune System Process Cellular Response To Organonitrogen Compound Defense Response Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Catalytic Activity Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Leukocyte Migration Response To Organonitrogen Compound	Membrane Depolarization Cell-cell Signaling Synaptic Transmission Regulation Of Membrane Potential Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Membrane Organization Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Synapse Structure Or Activity Ion Transmembrane Transport Regulation Of Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Clustering Protein Localization To Synapse Neurological System Process Positive Regulation Of Synaptic Transmission Regulation Of Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Nervous System Development Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Ion Transport Neuromuscular Process Regulation Of Respiratory Gaseous Exchange Regulation Of Signal Transduction Postsynaptic Membrane Organization Learning Regulation Of Long-term Neuronal Synaptic Plasticity Postsynaptic Membrane Assembly Receptor Localization To Synapse Cation Transmembrane Transport Presynaptic Membrane Assembly Membrane Hyperpolarization Regulation Of Synapse Organization Presynaptic Membrane Organization
Tagcloud ?		advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable	17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable	17q12 apical basolateral defining disc discs dlg2 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?