PTK2B and PTK2

Number of citations of the paper that reports this interaction (PubMedID 16760434)
49

Data Source:
BioGRID (genetic interference)
HPRD (in vitro)

		PTK2B	PTK2
Description		protein tyrosine kinase 2 beta	protein tyrosine kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Lamellipodium Cell Junction Dendrite Growth Cone Cell Projection Neuronal Cell Body Cell Body Perinuclear Region Of Cytoplasm Anchoring Junction Apical Dendrite Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Membrane Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activator Activity Ionotropic Glutamate Receptor Binding Neurotransmitter Receptor Regulator Activity	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding ATP Binding JUN Kinase Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding Molecular Function Activator Activity
	Biological Process	Angiogenesis Neuron Migration Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Adaptive Immune Response Marginal Zone B Cell Differentiation Immune System Process Protein Phosphorylation Apoptotic Process Cellular Defense Response Cytoskeleton Organization Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Actin Filament Polymerization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of Neuron Apoptotic Process Bone Resorption Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Protein-containing Complex Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Fluid Shear Stress Endothelin Receptor Signaling Pathway Regulation Of Postsynaptic Density Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of B Cell Chemotaxis	Angiogenesis Placenta Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cell-matrix Adhesion Heart Morphogenesis Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Cell Migration Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Detection Of Muscle Stretch Netrin-activated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Positive Regulation Of Wound Healing Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Macrophage Proliferation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis
Pathways		Signal regulatory protein family interactions VEGFA-VEGFR2 Pathway RHOU GTPase cycle Interleukin-2 signaling	Apoptotic cleavage of cellular proteins Regulation of actin dynamics for phagocytic cup formation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Signal regulatory protein family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RAF/MAP kinase cascade MET activates PTK2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling FCGR3A-mediated phagocytosis Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Fostamatinib	Endostatin 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral content ( 31790847) Bone mineral density ( 31790847) Crohn's disease ( 26192919) Dental caries ( 23259602) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Schizophrenia ( 29483656) Takayasu arteritis ( 30498034 25604533 33308445) White blood cell count ( 32888494)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30224653) LDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 27863252) Mood instability ( 31168069) Multisite chronic pain ( 33830993) Nickel levels ( 26025379) PR interval ( 32439900) Red cell distribution width ( 32888494) Response to interferon beta therapy ( 21502966) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		70 interacting genes: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAP4K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70	117 interacting genes: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 DOK4 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 HSPA13 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNB1 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 MISP MORC3 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PIK3R3 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SH2D1A SH2D1B SHC1 SKP2 SOCS1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TNS3 TP53 TRIM15 TRIO TRIP6 TSC2 VCL WEE2-AS1 YES1 ZFYVE21 ZNF331
Entrez ID		2185	5747
HPRD ID		03131	02859
Ensembl ID		ENSG00000120899	ENSG00000169398
Uniprot IDs		Q14289	A0A8Q3WLM4 B4DWJ1 E5RFW9 E7ESA6 Q05397 Q59GM6 Q59GN8
PDB IDs		2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32 4XEF 4XEK 4XEV 5TO8 5TOB 6LF3 7PLL 8XOX 8YGX	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO 4NY0 4Q9S 6I8Z 6LES 6PW8 6YOJ 6YQ1 6YR9 6YT6 6YVS 6YVY 6YXV 7PI4 7W7Z 7W8B 7W8I 7W9U
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Focal Adhesion Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Plasma Membrane Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Adhesion Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Kinase Activity Cytosol Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Cell Adhesion Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Kinase Activity Growth Hormone Receptor Signaling Pathway Cell Migration Leukocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Junction Regulation Of Cell-cell Adhesion Response To Growth Factor T Cell Costimulation Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Anchoring Junction ERBB Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune System Process Cell Motility Cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Kinase Binding Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Tyrosine Kinase Binding	Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Focal Adhesion Signal Transduction Cell Migration Cell Motility Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Tyrosine Kinase Activity Anchoring Junction Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Adhesion Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Regulation Of Apoptotic Process Response To Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Cellular Component Organization Ruffle Membrane Integrin-mediated Signaling Pathway Regulation Of Locomotion Regulation Of Immune System Process Protein Kinase Activity Intracellular Signal Transduction Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Protein Phosphorylation Receptor Complex Ephrin Receptor Signaling Pathway
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