RCC2

Description		regulator of chromosome condensation 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Midbody Early Endosome Membrane Chromosome, Centromeric Core Domain Mitotic Spindle Midzone
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Protein Kinase Binding Protein Domain Specific Binding Small GTPase Binding
	Biological Process	Integrin-mediated Signaling Pathway Regulation Of Fibroblast Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Migration Negative Regulation Of GTPase Activity Establishment Of Protein Localization Focal Adhesion Assembly Cell Division Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Passenger Complex Localization To Kinetochore Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Ruffle Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Non-melanoma skin cancer ( 29739929)
Interacting Genes		8 interacting genes: ANXA1 CEBPA ERG PRPF40A PTEN RAC1 RNF26 USP7
Entrez ID		55920
HPRD ID		18171
Ensembl ID		ENSG00000179051
Uniprot IDs		A0A024RAC5 Q9P258
PDB IDs		5GWN
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Cell Shape Regulation Of Ubiquitin-dependent Protein Catabolic Process Phagocytic Cup Regulation Of Cell Morphogenesis Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Cell Migration Macromolecule Metabolic Process Actin Filament Negative Regulation Of Cell Development Negative Regulation Of Transport Cytoskeleton Organization Cell Motility Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Hemopoiesis Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelial Cell Migration Multicellular Organismal-level Homeostasis CHOP-C/EBP Complex PML Body Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Wound Healing Response To Glucocorticoid
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