DNAJA2 and DYNLT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DNAJA2	DYNLT1
Description		DnaJ heat shock protein family (Hsp40) member A2	dynein light chain Tctex-type 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Heat Shock Protein Binding Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Protein Folding Positive Regulation Of Cell Population Proliferation Response To Heat Protein Refolding	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Neutrophil degranulation
Drugs
Diseases
GWAS		Factor VII activity ( 30642921)
Interacting Genes		10 interacting genes: DSCAM DYNLT1 DYRK3 ERG HSPA1A ITSN1 NEDD8 OGT PTEN UBC	48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2
Entrez ID		10294	6993
HPRD ID		07105	15987
Ensembl ID		ENSG00000069345	ENSG00000146425
Uniprot IDs		O60884	P63172
PDB IDs		7ZHS	5JPW 8J07 8PR0 8PR1 8PTK 8RGI
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Protein Tag Activity Protein Modification Process Positive Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Social Behavior Ubiquitin Protein Ligase Binding Regulation Of Synapse Organization Regulation Of Cell Junction Assembly Negative Regulation Of Synaptic Vesicle Clustering Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Post-embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Cellular Component Organization Netrin Receptor Binding Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Developmental Process Negative Regulation Of Protein Ubiquitination Denatured Protein Binding Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Clathrin-dependent Synaptic Vesicle Endocytosis Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Post-translational Protein Modification Synapse Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Phosphorus Metabolic Process Regulation Of Axonogenesis Nervous System Development Cell Projection Synapse Assembly Central Nervous System Development Regulation Of Nervous System Development Nucleoplasm Cytoplasm Protein Metabolic Process Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Biological Process Involved In Interaction With Host C3HC4-type RING Finger Domain Binding Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion
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